Registration Dossier
Registration Dossier
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EC number: 601-499-3 | CAS number: 117933-89-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- Sample was sent to Centre for Toxicology and Development Research (CEFT), Sri Ramachandra medical Centre, Chennai-600116, India
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 44 days
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Acute Eye Irritation/ Corrosion Study is performed in Newzealand white Rabbit as per OECD test guideline 405. The test performed is in-vivo in nature.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- in-vivo study is done for this Toxicity Parameter.
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane
- EC Number:
- 601-499-3
- Cas Number:
- 117933-89-8
- Molecular formula:
- C17H30O2
- IUPAC Name:
- 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 0.33
- Max. score:
- 0.33
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: Non-irritant as per OECD test guideline 405
- Conclusions:
- 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane did not cause any eye irritation in any of the NewZealand White rabbits during the test period.
So, 2-(2,4-Dimethylcyclohex-3-ene-1-yl)-5-methyl-(1-methylpropyl)-1,3-dioxane is classified as "Non-irritant" as per Harmonised Integrated Classification System .
The complete study was performed in compliance with OECD guidelines number 405.
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