Registration Dossier
Registration Dossier
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EC number: 219-547-3 | CAS number: 2459-10-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Scientific Opinion on the Safety Evaluation of the Substance, Trimethyl trimellitate, CAS No. 2459-10-1, for Use in Food Contact Materials
- Author:
- EFSA
- Year:
- 2 011
- Bibliographic source:
- EFSA Journal 2011; 9(2): 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Trimethyl benzene-1,2,4-tricarboxylate
- EC Number:
- 219-547-3
- EC Name:
- Trimethyl benzene-1,2,4-tricarboxylate
- Cas Number:
- 2459-10-1
- Molecular formula:
- C12H12O6
- IUPAC Name:
- 1,2,4-trimethyl benzene-1,2,4-tricarboxylate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
Applicant's summary and conclusion
- Conclusions:
- No toxicity nor decrease in the ratio of polychromatic erythroctes were seen up to the maximum recommended dose of 2000 g/kg bw.
- Executive summary:
A mammalian erythrocyte micronucleus test has been conducted in mice. No toxicity nor decrease in the ratio of polychromatic erythroctes were seen up to the maximum recommended dose of 2000 g/kg bw.
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