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EC number: 441-070-6 | CAS number: 61826-76-4
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 441-070-6
- EC Name:
- -
- Cas Number:
- 61826-76-4
- Molecular formula:
- C14H11NO2
- IUPAC Name:
- (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile
Constituent 1
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 2.27 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- < 24 h
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- > 0.01 s-1
- DT50:
- < 0.05 h
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- < 24 h
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- > 0.005 s-1
- DT50:
- < 0.05 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 24 h
Any other information on results incl. tables
Due to the fast hydrolyses at pH 7 and pH 9 the concentration of the test substance could not be determined. The test substance was complete hydrolysed and only the hydrolyses product could be determined. For the estimation of the half life time of the test substance at pH 7 and pH 9 therefore as start concentration the initial amount of the test substance and the time of preparing this solution and as finished concentration the injection time of the first HPLC-injection and the detection limit of the test substance was chosen. More than 50% of the test item hydrolysed in 2.4 hours at 50 °C. According to the Directive it is estimated that the half life of the test item in aqueous solution at 25 °C is less than one day. The test item is not stable to hydrolysis at each of pH´s tested. Because of the fast hydrolysis of the test substance it can not be judged if the hydrolysis followed a first order kinetic. The test item is relatively more stable in acid than in neutral and alkaline solutions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- More than 50% of the test item hydrolysed in 2.4 hours at 50 °C. According to the Directive it is estimated that the half life of the test item in aqueous solution at 25 °C is less than one day
- Executive summary:
More than 50% of the test item hydrolysed in 2.4 hours at 50 °C. According to the Directive it is estimated that the half life of the test item in aqueous solution at 25 °C is less than one day
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