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Diss Factsheets

Administrative data

boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-08-07 - 2018-08-23
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
according to guideline
OECD Guideline 103 (Boiling Point)
GLP compliance:
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
1-benzyl-5-phenylbarbituric acid
EC Number:
EC Name:
1-benzyl-5-phenylbarbituric acid
Cas Number:
Molecular formula:
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Molecular Formula : C17H14N2O3
Molecular Weight : 294.3
Physical Appearance : White powder
CAS No. : 72846-00-5
Batch Number : 170240
Purity : 99.5%

Results and discussion

Boiling point
Key result
Boiling pt.:
342.8 °C
Atm. press.:
1 013 hPa

Applicant's summary and conclusion

Based on the results obtained in the study it is concluded that the boiling point of 1-Benzyl-5-
phenylbarbituric acid (BPBA) is 342.80 °C at 92.23 kPa atmospheric pressure.
Executive summary:

The study, entitled "Determination of Boiling Point / Boiling Range of 1-Benzyl-5-phenylbarbituric

acid (BPBA)" was performed in compliance with the Study Plan No. P/PCP2728/BP/18, which

incorporated the recommendations made in the guideline OECD 103.

The boiling point of test item was determined by differential scanning calorimetry. The performance

of the instrument was checked before start of test using Indium for temperature (onset) and heat

flow accuracy. The performance of the instrument was found satisfactory.

Samples of the test item and a reference material are subjected to same temperature programme.

When the sample undergoes transition involving a change in enthalpy (endothermic reaction on

boiling), that change was indicated by a departure from baseline of heat flow record. The boiling

point was determined with the help of thermogram. The midpoint of the endothermic peak was

considered as boiling point of test item. Atmospheric pressure (kPa) was recorded during the

determination of boiling point. Duplicate determinations were made and mean of two samples was

taken as boiling point of test item.

The boiling points of two samples of test item were found to be 342.41ºC and 343.19 ºC

respectively. The boiling points of two samples of test item were found within the accuracy of

Differential Scanning Calorimetric Method ( ± 2.0 K ). The mean boiling point was found to be

342.80 ºC.

Based on the results obtained in the study, the Boiling Point of 1-Benzyl-5-phenylbarbituric acid

(BPBA) is found to be 342.80 °C at 92.23 kPa atmospheric pressure.