Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 February 2018 - 05 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
0.036 g/L
Conc. based on:
test mat.
Incubation duration:
3 d
Temp.:
20 °C
pH:
>= 4.46 - <= 6.18
Details on results:
The solubility of test item at pH 4.49 – 6.18 in water is 0.0358 g/L.

Results on preliminary test:

0.1g in x mL of solution

0.1

0.5

1

2

10

100

> 100

Soluble (+/-)

-

-

-

-

-

-

+

Approximate solubility, g/L

> 1000

1000 to 200

200 to 100

100 to 50

50 to 10

10 to 1

<1

Results of water solubility:

Mixing timeat 30 ºC

[days, flasks]

1

2

3

Samples

1

2

3

4

5

6

Temperature, ºC

19.7

19.9

19.9

pH

6.18

4.65

4.49

Concentration, g/kg

0.0383

0.0351

0.0376

0.0334

0.0360

0.0341

Average concentration, g/kg

0.0367

0.0355

0.0351

Average concentration, g/kg

0.0358

The solubility in water is 0.0358 g/kg. The density of this solution is about 1 kg/L (about water density).

Conclusions:
The water solubility at 20 ± 0.5 ºC and at pH ranging 4.49 – 6.18 is 0.0358 g/L.
Executive summary:

The water solubility determination was performed according to OECD Guideline 105 and EU Method A.6 (GLP study). The flask method was used. The test item measurement both in was conducted with a validated GC-FID method. The water solubility at 20 ± 0.5 ºC and at pH ranging 4.49 – 6.18 is 0.0358 g/L.

Description of key information

Key study: OECD Guideline 105 and EU Method A.6. GLP study. The water solubility at 20 ± 0.5 ºC and at pH ranging 4.49 – 6.18 is 0.0358 g/L.

Key value for chemical safety assessment

Water solubility:
0.036 g/L
at the temperature of:
20 °C

Additional information