Tetrakis(diethyldithiocarbamato-S,S')tellurium

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tetrakis(diethyldithiocarbamato-S,S')tellurium

EC Number:

244-121-9

EC Name:

Tetrakis(diethyldithiocarbamato-S,S')tellurium

Cas Number:

20941-65-5

Molecular formula:

C20H40N4S8Te

IUPAC Name:

N2,N2,N6,N6,N6,N6,N9,N9-octaethyl-1λ³,3,5λ³,5λ³,7,7,8λ³,10-octathia-4λ⁸-telluradispiro[3.3⁴.3⁴.3⁴]trideca-1,5,5,8-tetraene-2,6,6,9-tetramine

Test material form:

solid

Specific details on test material used for the study:

- Name of the test item (as cited in study report): Tellurium diethyldithiocarbamate
- Batch No.: MT-5D 494
- Appearance: Yellow, powder

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River (UK) Ltd., Manston Road, Margate, Kent, England
- Weight at study initiationt: 282-300g for males and 237-250 for females
- Age at study initiation: 4-6 weeks
- Housing: Rats were housed individually in metal cages with wire mesh floors
- Diet: Labsure LAD 1 (ad libitum)
- Water: tap water (ad libitum)
- Acclimation period: 7 days

ENVIRONMENT
- Temperature: 20-22 °C
- Humidity: 63%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

A group of ten rats (five males and five females) was treated with a single dose of 5 g/kg bw. The test substance was prepared at 50% w/v in distilled water and administered at a volume of 10.0 ml/kg

Doses:

5 g/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of examination: Twice daily for clinical signs. On Days 1, 2, 3, 5, 8, 11 and 15, body weight was measured
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

There were no mortalities following a single oral dose of test substance at 5.0 g/kg bodyweight.

Clinical signs:

other: Pilo-erection was seen in all rats shortly after dosing. On Day 2 soft faeces were observed for all animals. No other signs of reaction to treatment were observed. Recovery was judged by external appearance and behaviour was apparently complete by Day 3.

Gross pathology:

Terminal autopsy findings were normal.

Any other information on results incl. tables

TABLE 1 Individual bodyweights (g) of rats dosed orally with tellurium diethyldithiocarbamate

 

Sex	Bodyweight (g) at Day
	1	2	3	5	8	11	15
m	282 286 296 300 299	315 304 318 320 319	309 295 326 340 329	328 320 346 355 354	339 336 366 377 378	353 354 398 390 402	366 370 424 409 430
f	242 244 240 237 250	264 259 252 250 263	256 253 251 243 275	270 260 250 250 277	273 265 263 252 285	276 274 264 268 293	280 277 264 267 305

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met