Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental phase: 17 October 2017 to 23 March 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Turbidity Method
- Key result
- Water solubility:
- 2.807 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 21 °C
- pH:
- > 6 - < 10
- Conclusions:
- The water solubility of the test substance was determined to be 2.807 mg/L at 21°C.
- Executive summary:
Introduction
The water solubility of the test substance was measured using the turbidity method in accordance with EU Method A6 (water solublity)
Method
A sample stock of the test item in tetrahydrofuran (THF) was prepared. A sample solution in water was prepared from this stock and used to establish a suitable starting concentration for the turbidity measurement which was subsequently determined to be 1 % w/w in water.
Turbidity measurements were made using a Hach 2100N Turbidimeter. The solution was diluted by diluting from 50.0 mL to 100.0 mL with filtered water. The turbidity of this solution was measured and the process repeated until five consecutivemeasurements were made with no significant change in turbidity value. The test was performed in duplicate. Two straight lines were obtained using the first six and last six data points and water solubility was calculated as the inverse log of the intercept.
Results
Result
Water Solubility (mg/L)
Duplicate 1
3.029
Duplicate 2
2.585
Average
2.807
Conclusion
The water solubility of the test substance was determined to be 2.807 mg/L at 21 °C.
Reference
Results of turbidity measurments for the duplicates are presented in the table below:
Result |
Water Solubility (mg/L) |
Duplicate 1 |
3.029 |
Duplicate 2 |
2.585 |
Average |
2.807 |
Description of key information
Water solubility of the test substance.
Key value for chemical safety assessment
- Water solubility:
- 2.807 mg/L
- at the temperature of:
- 21 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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