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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-5-chlorobenzophenone
EC Number:
211-949-7
EC Name:
2-amino-5-chlorobenzophenone
Cas Number:
719-59-5
Molecular formula:
C13H10ClNO
IUPAC Name:
(2-amino-5-chlorophenyl)(phenyl)methanone
Test material form:
solid: particulate/powder

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Details on test solutions:
The test item was not soluble in the test medium. A special solubilisation protocol was carried out before the experimentation, according to the OECD 23 guidance document. This method consisted in stirring each test item nominal concentrations in test medium during 24h, in the dark dans 20°C.

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
other: test medium
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
19.5 - 20°C
pH:
7.6 - 8
Dissolved oxygen:
8.9 - 9.2
Nominal and measured concentrations:
Nominal loading rate : 1, 1.8, 3.2, 5.8, 10.5 and 18.9 mg/L
Test item at the start : /, /, 3.22, 5.80, 10.51 and 18.91 mg
Remarque : for technical feasability issues, both concentrations (1 and 1.8 mg/L) were diluted from the water accomodated fraction (WAF) 18.9 mg/L.

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
24 h
Dose descriptor:
EL50
Effect conc.:
9.4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (dissolved fraction)
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
8.4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (dissolved fraction)
Basis for effect:
mobility

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The toxicity to aquatic invertebrates was determined according to OECD 202 guideline on Daphnia magna. The study shows the following results :
- EL50 - 24h = 9.4 mg/L
- EL50 - 48h = 8.4 mg/L
In regard with GHS criteria, the test substance could be considered as toxic for aquatic invertebrates.
Executive summary:

The toxicity to aquatic invertebrates was determined according to OECD 202 guideline on Daphnia magna. The study shows the following results :

- EL50 - 24h = 9.4 mg/L

- EL50 - 48h = 8.4 mg/L

In regard with GHS criteria, the test substance could be considered as toxic for aquatic invertebrates.