Hydroxyacetone

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-09-25 - 2018-10-12

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

27 Jul 1995

Deviations:

yes

Remarks:

please refer to 'Principles of method if other than guideline'

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

24 Jan 2014

Deviations:

yes

Remarks:

please refer to 'Principles of method if other than guideline'

Principles of method if other than guideline:

The following deviation from the guidelines was observed:
As the test item is highly soluble in water, it was not possible to weigh the fivefold saturation concentration of the test item in water in order to perform a main test as described in the guidelines. This is stated as uncritical, because there is no alternative option.
The deviation was assessed and stated by the study director on 02. Oct. 2018.

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

The test item was stored in the test facility in a closed vessel at room temperature (20 ± 5 °C).

Key result

Water solubility:

> 100 other: kg/L

Conc. based on:

test mat.

Remarks on result:

completely miscible

Details on results:

After the pre-test, the solubility of the test item Hydroxyacetone in water was determined as > 100 kg/L. Therefore, it was not possible to weigh the fivefold saturation concentration of the test item in water in order to perform a main test as described in the guidelines.
Consequently a main test using a simplified flask method with abbreviated equilibration times was performed to evaluate the magnitude of the water solubility of the test item.
The results of the main test indicate that Hydroxyacetone is miscible with water in all proportions at 20.0 ± 0.5 °C.

PRE-TEST

In a non-GLP pre-test, 10 g of the test item was mixed with 0.1 mL water. Complete dissolution was observed.

MAIN TEST

Since it was known that the test item is very well soluble in water, 1 and 10 g test item were mixed with 0.1, 1, 2, 5 and 10 mL of demineralised water at constant temperature 20.2 -20.5 °C.

When mixing water and test item at 20 ± 0.5 °C, no streaks were visible. Therefore no shaking of the mixtures was necessary. The test item was dissolved completely in all cases (visual judgement). The visual judgement was confirmed with a Laser pointer exemplarily. No Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid) could be observed indicating that no colloidal dispersed particles or micelles were present.

Conclusions:

The results of the main test indicate that Hydroxyacetone is miscible with water in all proportions at 20.0 ± 0.5 °C.

Executive summary:

The determination of the water solubility of Hydroxyacetone was performed according to GLP using a simplified flask method as a guideline compliant test cannot be performed due to observed high water solubility (pre-test results)

After mixing 1 and 10 g test item, respectively, with 0.1, 1, 2, 5 and 10 mL demineralised water at 20.2°C - 20.5 °C, Hydroxyacetone was completely dissolved (visual judgement). In addition, no Tyndall effect was noted at exemplarily measurements using a laser pointer, confirming the complete dissolution.

Thus, it is not possible to weigh the fivefold saturation concentration of the test item in water in order to perform a main test according to the guidelines.

Therefore, it is stated, that Hydroxyacetone is miscible with water in all proportions (water solubility > 100 kg/L).

Description of key information

The determination of the water solubility of Hydroxyacetone was performed according to GLP using a simplified flask method as a guideline compliant test cannot be performed due to observed high water solubility (pre-test results)

After mixing 1 and 10 g test item, respectively, with 0.1, 1, 2, 5 and 10 mL demineralised water at 20.2°C - 20.5 °C, Hydroxyacetone was completely dissolved (visual judgement). In addition, no Tyndall effect was noted at exemplarily measurements using a laser pointer, confirming the complete dissolution.

Thus, it is not possible to weigh the fivefold saturation concentration of the test item in water in order to perform a main test according to the guidelines.

Therefore, it is stated, that Hydroxyacetone is miscible with water in all proportions (water solubility > 100 kg/L).

Key value for chemical safety assessment

Water solubility:

100 000 g/L

at the temperature of:

20 °C