Hydroxyacetone

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-04-26 - 2018-09-27

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

31 May 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

The test item was stored in a tightly closed vessel at room temperature (15.8 - 23.0°C)

Key result

Melting / freezing pt.:

< 67.26 °C

Decomposition:

no

Sublimation:

no

Remarks on result:

other: no atm. press. stated in the report

Melting / freezing pt.:

> -80 - < -20 °C

Decomposition:

no

Sublimation:

no

Remarks on result:

other: based on the pre-test, no atm. press. stated in the report

PRE-TEST

Table: Values Pre-Test

Room temperature	5.0 °C	-20.1 °C	-80 °C
clear colourless liquid	same as at room temperature		solid like ice

DSC MEASUREMENT OF THE TEST ITEM

No event was detected till -66.24 °C at first determination and no event till -67.26 °C at second determination.

Interpretation

During the DSC measurements, no events were detected which could indicate a melting or freezing point.

As the lowest measurement temperature of the DSC instrument was - 67.26°C, the melting point should be stated as < - 67.26°C.

Conclusions:

The melting point was determined via DSC (differential scanning calorimetry)
Based on to the pre-test the melting point should be between -20 °C and -80 °C.
During the DSC measurements, no events were detected which indicate a melting or freezing point.
As the lowest measurement temperature of the DSC instrument was - 67.26°C, the melting point should be stated as < - 67.26°C.

Executive summary:

The melting point was determined via DSC (differential scanning calorimetry) according to OECD 102 resp. EU A.1 and under GLP conditions.

Based on to the pre-test the melting point should be between -20 °C and -80 °C.

During the DSC measurements, no events were detected which indicate a melting or freezing point.

As the lowest measurement temperature of the DSC instrument was - 67.26°C, the melting point should be stated as < - 67.26°C (205.89 K).

No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Description of key information

The melting point was determined via DSC (differential scanning calorimetry) according to OECD 102 resp. EU A.1 and under GLP conditions.

Based on to the pre-test the melting point should be between -20 °C and -80 °C.

During the DSC measurements, no events were detected which indicate a melting or freezing point.

As the lowest measurement temperature of the DSC instrument was - 67.26°C, the melting point should be stated as < - 67.26°C (205.89 K).

No observations were made which might cause doubts on the validity of the study outcome. Therefore, the result of the study is considered valid.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

67.26 °C

Additional information

Because during the DSC measurements, no events were detected which indicate a melting or freezing point the lowest measurement temperature of the DSC instrument is stated as melting point. No pressure is stated. Nevertheless the measured melting point was obverved at room conditions, therefore a pressure of 101 325 Pa is applicable as key value for the CSA.