2-ethyl-4-hydroxy-5-methylfuran-3(2H)-one

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

1

Reference substance name:

2-ethyl-4-hydroxy-5-methylfuran-3(2H)-one

EC Number:

248-514-6

EC Name:

2-ethyl-4-hydroxy-5-methylfuran-3(2H)-one

Cas Number:

27538-10-9

Molecular formula:

C7H10O3

IUPAC Name:

2-ethyl-4-hydroxy-5-methylfuran-3(2H)-one

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Test conditions

Hardness:

149.3 mg.L-1 of CaCO3

Test temperature:

20.3

pH:

7.8

Dissolved oxygen:

8.1

Conductivity:

447 μS.cm-1

Nominal and measured concentrations:

Nominal concentrations: 100mg.L-1.

Reference substance (positive control):

yes

Results and discussion

Effect concentrations

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Results with reference substance (positive control):

The 24-hours EC50 value of the reference substance (potassium dichromate) was 1.02 mg.L-1 (95% confidence limits = 0.88 to 1.19 mg.L-1), showing the sensitivity of the test system (ISO 6341 / OECD 202, 2004).

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The 48-hours EC50 value was not determined because the highest tested concentration of Furanone Homo, 100 mg.L-1, did not cause immobility to the test organisms. Therefore the 48-hours EC50 value of the tested substance is higher than 100 mg.L-1.