Registration Dossier
Registration Dossier
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EC number: 291-768-8 | CAS number: 90480-35-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-07-17 to 2017-07-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 111 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6.6
- Remarks on result:
- other: Mean of 24, 48 and 72h samples
- Conclusions:
- The water solubility of the test item was determined at 20 ± 0.5°C to be 111 mg/L (pH 6.6).
- Executive summary:
In the current study the water solubility of the test item was determined according to OECD 105, using flask method. The test was performed over 24, 48 and 72 hours and the average water solubility was calculated. Since the substance is an UVCB, the recovery of the test item was calculated as the sum of all significant signals. The water solubility of the test item was determined at 20 ± 0.5°C to be 111 mg/L (pH 6.6).
Reference
Method validation:
- Linear from 0.5 to 50 mg/L, R2 ≥ 0.992
- LOD: not deemed necessary as S/N ratio ≥ 30
- LOQ: 10 mg/L
- Accuracy: 97% and 92% at 1 x LOQ and 5 x LOQ respectively
- Method was found to be precise and specific.
- Recovery: 90 -94 %
Tyndall effect
Negative results after 24, 48 and 72h.
Test results main study
- pH remained constant, ranging between 6.282 and 6.767.
| Pre-incubation time | Replicate | concentration (mg/L) | Mean concentration (mg/L) |
| 24h | 1 | 112 | 110 |
| 2 | 108 | ||
| 48h | 1 | 110 | 112 |
| 2 | 115 | ||
| 72h | 1 | 111 | 111 |
| 2 | 112 | ||
| Mean | 111 | ||
| std deviation | 2.2 | ||
The test item was quantified based on the sum of all significant signals.
Description of key information
The water solubility of the test item was determined according to OECD 105, using flask method. The test was performed over 24, 48 and 72 hours and the average water solubility was calculated. The water solubility of the test item was determined at 20 ± 0.5°C to be 111 mg/L (pH 6.6).
Key value for chemical safety assessment
- Water solubility:
- 111 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
