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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 Novembre 2015 to 05 May 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Version / remarks:
The determination was carried out using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
GLP compliance:
yes
Type of method:
HPLC estimation method
Specific details on test material used for the study:
Identification:1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2(phenylmethyl) ester
Physical state/appearance: Clear colorless liquid
Lot: 0900
Purity: 98.8%
Expiry: 22 October 2016
Storage conditions: Room temperature, in the dark
Details on study design: HPLC method:
A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System
:
Agilent Technologies 1200 series
Column
:
Waters XSelect HSS Cyano 5 μm (150 x 4.6 mm id)
Column temperature
:
30 ºC
Mobile phase
:
Methanol: purified water (55:45 v/v)
pH of mobile phase
:
5.7
Flow-rate
:
1.0 mL/min
Injection volume
:
10 μL
UV detector wavelength
:
210 nm dead time and standards
207 nm sample
Analytical monitoring:
yes
Key result
Type:
Koc
Value:
16 300 dimensionless
Key result
Type:
log Koc
Value:
4.21 dimensionless
Conclusions:
The adsorption coefficient (Koc) of the test item has been determined to be 1.63 x 10^4, log10Koc 4.21.
Executive summary:

The determination of the test material 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2(phenylmethyl) ester was carried out using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The testing determined that the adsorption coefficient (Koc) of the test item was 1.63 x 10^4, log10Koc 4.21.

Description of key information

The determination of the test material 1,2-Cyclohexanedicarboxylic Acid, 1-butyl 2(phenylmethyl) ester was carried out using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The testing determined that the adsorption coefficient (Koc) of the test item was 1.63 x 10^4, log10Koc 4.21.

Key value for chemical safety assessment

Additional information