Registration Dossier
Registration Dossier
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EC number: 701-266-7 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only a summary table with results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were fed differenct doses of test material and the LD50 was estimated.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Polyethylene polyamine, pentaethylenehexamine fraction
- EC Number:
- 701-266-7
- Molecular formula:
- Complex UVCB substance
- IUPAC Name:
- Polyethylene polyamine, pentaethylenehexamine fraction
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20%
- Doses:
- 1.0, 2.0, 3.98 g/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2/2 rats died at 3980 mg/kg bw; 1/2 rats died at 2000 mg/kg bw, 0/2 rats died at 1000 mg/kg bw
- Clinical signs:
- other: Animals appeared normal during and after feeding of 1000 mg/kg bw of test substance. No further information is given.
- Gross pathology:
- At 1000 mg/kg bw gross pathology appeared essentially negative. No further information is given.
Any other information on results incl. tables
g/kg |
No animals dead |
Reponse-remarks |
1.0 |
0/2 |
Animals appeared normal during and after feeding. Gross pathology at autopsy appeared essentially negative. |
2.0 |
1/2 |
Animals died 8 days following feeding. |
3.98 |
2/2 |
One animal died in 2 hours the other In 4 days. |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS Category 4 (H302) according to Regulation (EC) No 1272/2008
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