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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

EC50 (72h) = 19 mg/L, EC0 (72h) = 2 mg/L (active ingredient, growth rate/biomass) for Desmodesmus subspicatus (DIN 31482, read-across)
EC50 (72h) = 2.196 mg/L, NOEC (72h) = 1.63 mg/L (active ingredient, growth rate) for Skeletonema costatum (ISO 10253)

Key value for chemical safety assessment

EC50 for freshwater algae:
19 mg/L
EC50 for marine water algae:
2.196 mg/L
EC10 or NOEC for freshwater algae:
2 mg/L
EC10 or NOEC for marine water algae:
1.63 mg/L

Additional information

No study investigating the toxicity of D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salts (CAS 383178-66-3) to freshwater algae is available. Thus, an analogue substance (D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, CAS 110615-47-9) is used in a read across approach to assess the algal toxicity of the target substance to freshwater algae. The read across is based on structural similarity between the target substance and the supporting substance. The target substance is a derivative of the supporting substance, where a carboxymethy group is added to a -OH function. All other structural elements (alkyl side chain, glycoside moiety) are identical. The additional carboxymethyl group renders the substance more hydrophilic, which usually decreases aquatic toxicity. This is confirmed by the acute ecotox data of the target substance (TS) and the supporting substance (SS): Fish: 7.1 mg/L (TS) vs 3.0 mg/L (SS); Invertebrates: 172 mg/L (TS) vs 7.0 mg/L (SS). Therefore, read across from D-Glucopyranose, oligomeric, C10-16-alkyl glycosides to D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salt is fully justified as this is considered to be a worst case approach.

The toxicity of the read across substance to freshwater algae was investigated according to DIN guideline 31482 part 9 and GLP using Desmodesmus subspicatus as test organism (Rieche 1994). The static study tested concentrations between 1 and 128 mg/L. Based on nominal concentrations the 72h-EC50 value for growth rate is determined to be 19 mg a.i./L and the 72h-EC0 value for biomass is determined to be 2 mg a.i./L, respectively.

In addition, one study is available investigating the toxicity of D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salts (CAS 383178-66-3) to marine algae (Hudson 2003). The study was performed according to ISO guideline 10253 and GLP using Skeletonema costatum as test organism. The static study tested concentrations between 0.3 and 3 mg a.i/L. The validity criteria are fulfilled. The 72h-EC50 value for growth rate was determined to be 2.196 mg a.i./L and the 72h-EC10 value was determined to be 1.63 mg a.i./L based on the nominal test concentration.