Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes
Test material
- Reference substance name:
- catena-((μ4-sulfato)-(μ2-glycinato)-manganese
- Cas Number:
- 2087529-10-8
- Molecular formula:
- Mn(SO4)(C2H5NO2)
- IUPAC Name:
- catena-((μ4-sulfato)-(μ2-glycinato)-manganese
- Test material form:
- solid
Constituent 1
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- percent corneal swelling
- Value:
- 0
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Value:
- 0
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this in vitro eye irritation study, using the Isolated Chicken Eye model with MANGANESE GLYCINATE, no ocular corrosion or severe irritation potential was observed. The overall ICE score was 2xI, 1xII in the first and the additional experiment.
According to the guideline OECD 438, MANGANESE GLYCINATE is categorized as “No Category”.
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