[No public or meaningful name is available]

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Preliminary study:

the preliminary test for manganese glycinate was conducted at 50 +/-0,5Cin buffer pH 4,7, and 9 buffer solutions for a period of 5 days .

Test performance:

Total manganese content remains unchanged.

Transformation products:

no

Remarks on result:

other: anganese glycinate may not be hydrolysed in buffer pH 4and pH 7

Details on results:

Hydrolysis samples couldn't be analysed due to interaction of metal complex with the LOCK signal of NMR.
Hydrolysis sample were analysed by ICP-OES nd Day 0 and Day 5 at 50 =?-0,5 to determine the total manganese content in thetest item. Result show that the totla manganese content remains unchanged.
Physical observations were made and the test item was found to be soluble in pH aqueus buffers 4,7 and 9 solutions. Slight white color turbidity was observed in pH 7 buffer solution. No physical changes were observed in pH 4 and pH 7 buffer solution after 5 days of incubation at 50Cand color change was observed in pH7 buffer solutions.

Validity criteria fulfilled:

yes

Conclusions:

On the basis of test results, manganese glycinate may not be hydrolysed in buffer pH 4and pH 7 at 50 +/- 0,5C for 5 days. The color change in the pH9 may be attributed to the hydrolysis of test item at 50 +/- 0,5C for 5 days.

Description of key information

On the basis of  test results, manganese glycinate may not be hydrolysed in buffer pH 4and pH 7  at 50 +/- 0,5C  for 5 days. The color change in the pH9 may be attributed to the hydrolysis of test item at  50 +/- 0,5C  for 5 days.