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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08 August 2017 - 05 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
1 136 g/L
Conc. based on:
test mat. (dissolved fraction)
Remarks:
yttrium trichloride hexahydrate, calculated based on measured dissolved yttrium concentrations
Loading of aqueous phase:
2 000 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
25 °C
pH:
2
Remarks on result:
other: mean of 24, 48 and 72 h
Water solubility:
333 g/L
Conc. based on:
element (dissolved fraction)
Remarks:
yttrium
Loading of aqueous phase:
2 000 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
25 °C
pH:
2
Remarks on result:
other: mean of 24, 48 and 72 h
Details on results:
From the preliminary test, the solubility of the test item was determined to be > 1000 g/L (see "Any other information on results incl. tables").
Therefore, it was decided to perform the main test according to the flask method (for results see "Any other information on results incl. tables").

Results were validated by:
- Linearity validation: The analysis showed a good linearity of the method (r > 0.99).
- Accuracy validation: Results in dilution mixture showed a good accuracy which indicates acceptable data (recoveries ranged between 70 and 110%).
- Repeatability validation: The results indicated a good precision of the data (RSD < 20%).
- Specificity: The intensity (CPS) of blank samples measured was negligible.
- Limit of quantification: 125 g Y/L (limit of detection: 25 g Y/L).

Results of the preliminary test with milliQ water at pH 6 or buffer solution at pH 4, 7 or 9 identical results):

Amount of test item weighed (g) 0.1  0.1  0.1  0.1
Volume of water added (mL) 0.1 (pH 6)  0.1 (pH 4)  0.1 (pH 7) 0.1 (pH 9)
Solubility (yes/no) Yes  Yes   Yes   Yes

Results of the main test:

 

Incubation time

 
 

Solubility expressed as

yttrium content in water (g/L)


 

Solubility of yttrium trichloride hexahydrate in water*(g/L)

 

  

Mean pH measured

  

Temperature (°C)

Test 1

24h

340 

1159

2

25

Test 2

48h 333 1136 2 25

Test 3 (mean of 2 determinations)

72h 327 1115 2 25

Mean

24h, 48h and 72h

333

1136

2

25

* extrapolation using the conversion factor e = Mw YCl3.6H2O / Mw Y = 303.4/88.9 = 3.41

Conclusions:
The mean solubility in water at pH 2 and 25°C is 1136 g/L when expressed as yttrium trichloride hexahydrate and 333 g/L when expressed as yttrium content in water (flask method).

Description of key information

Based on a study performed according to OECD guideline 105 (Jean-Baptiste, 2018; Klimisch 1), the mean solubility of the test item in water is 1136 g/L (yttrium trichloride hexahydrate/L) at pH 2 and 25°C, calculated based on a mean measured dissolved yttrium concentration of 333 g Y/L (flask method).

Key value for chemical safety assessment

Water solubility:
1 136 g/L
at the temperature of:
25 °C

Additional information