Registration Dossier
Registration Dossier
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EC number: 701-263-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The dermal and eye irritancy of the diglycidyl ether of bisphenol F is determined to be slightly to not irritating and not irritating based on the Klimisch 1 and 2 studies performed using OECD guidelines.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The dermal irritancy of the diglycidyl ether of bisphenol F is determined to be slightly to not irritating based on the six Klimisch 1 and 2 studies performed using OECD guidelines.
Under the experimental conditions employed only one product induced erythema and edema reactions above the threshold of significance (score 2 for erythema or edema) and classified as irritant according to the EEC directive No. 83/467/1983. The other studies indicated slight irritancy, but not enough to meet the threshold for classification.
Two cumulative repeat dose irritation studies were performed and under the experimental conditions employed test materials induced significant irritation after repeated application and there is a cumulative skin irritation potential in albino rabbits.
The eye irritancy of the diglycidyl ether of bisphenol F is determined to be not irritating based on the four Klimisch 1 and 2 studies performed using OECD guidelines. In the rabbit eye irritancy tests, 0.1 mL of the test material caused no irritation and no initial pain response.
Effects on skin irritation/corrosion: slightly irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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