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Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

Administrative data

Endpoint:
toxicity to soil macroorganisms except arthropods: long-term
Type of information:
experimental study planned
Justification for type of information:
As the test substance has a high potential to adsorb to the soil, the test substance belongs to Hazard category 3 as per Table R.7.11—2 in the ECHA guidance R.7c. In the absence of toxicity data under this category, the guidance recommends performing the risk assessment using modified EPM method (i.e., PEC × 10 / PNECscreen) and conducting one confirmatory long-term soil toxicity testing. Therefore, long-term test with terrestrial invertebrates has been planned with the test substance. Nevertheless, the outcome of the chemical safety assessment using modified EPM method indicates no risk for the soil compartment (PECx10/PNEC soil <1).
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
data waiving: supporting information
Reason / purpose for cross-reference:
data waiving: supporting information
Reference

Using the HPLC method at neutral pH and soil-adsorption-reference data, the log Koc of di-TMPTTA for the major component was determined to be 3.61. The minor components had log Koc values between < 1.26 and > 5.63.

The upper limit log Koc value of 3.61 (Koc: 4000) for the major constituents representing ≥60% of the UVCB substance composition has been considered further for risk assessment.

Koc at 20 °C:
4 000

The HPLC method at neutral pH using soil-adsorption reference data was applied for the determination of the adsorption coefficient of di-TMPTTA in accordance with OECD Guideline 121 and EU Method C.9. The mobile phase was 55/45 (v/v) methanol/water. The column temperature was 35°C. In the HPLC chromatogram, one major peak (66% peak area) and 23 smaller peaks (0.02 - 11% peak area) were observed. The log Koc value for the major component was 3.61 (Koc: 4,000). The log Koc values for the minor components ranged from < 1.26 to > 5.63 (Koc from < 18 to > 4.3E+5) (Lammers 2013).

The upper limit log Koc value of 3.61 (Koc: 4000) for the major constituents representing ≥60% of the UVCB substance composition has been considered further for risk assessment. No further supporting data (e.g., using QSAR) has been generated, as the value already exceeds the threshold of 3, indicating a high soil adsorption potential leading to worst case risk assessment.

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))

Test material

Constituent 1
Chemical structure
Reference substance name:
2-({2,2-bis[(prop-2-enoyloxy)methyl]butoxy}methyl)-2-[(prop-2-enoyloxy)methyl]butyl prop-2-enoate
EC Number:
830-217-3
Cas Number:
1393932-71-2
Molecular formula:
Not applicable for this UVCB
IUPAC Name:
2-({2,2-bis[(prop-2-enoyloxy)methyl]butoxy}methyl)-2-[(prop-2-enoyloxy)methyl]butyl prop-2-enoate
Test material form:
liquid

Results and discussion

Applicant's summary and conclusion