Registration Dossier
Registration Dossier
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EC number: 700-590-6 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- - Lot/batch No.: CM71217681
- Storage condition of test material: room temperature in the dark
-Other: water solubility ≤ 0.138 mg/L at 20 deg. C
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- > 9.4
- Temp.:
- 30 °C
- pH:
- 6.6
- Details on results:
- The HPLC chromatogram of the test material (attached as Figure 3) shows the test substance contains a mixture of components each eluting at retention times > 40 min. The partition coefficient determined by extrapolation from the calibration curve indicates a logPow value of > 9.4
Any other information on results incl. tables
Table 3: Results of HPLC Determination of Partiton Coefficient
Injection |
Retention Time (min) |
Capacity Factor (k) |
Log k |
Log Pow |
1 |
> 29.665 |
> 17.6 |
> 1.25 |
> 9.4 |
2 |
> 29.665 |
> 17.6 |
> 1.25 |
> 9.4 |
HPLC chromatogram is attached as Figure 3
Applicant's summary and conclusion
- Conclusions:
- The logPow of the test substance was determined to be > 9.4 indicating a strong potential to bioaccumulate in the environment.
- Executive summary:
The partition coefficient of the test substance was determined by an HPLC method according to EU method A.8.
The partition coefficient values determined for the substance are: Pow = 2.51 x 109 and logPow > 9.4
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