Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-674-6 | CAS number: 109-46-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact allergy and cross reactivity to substituted tiourea compounds.
- Author:
- Roberts, J.L.and Hanifin
- Year:
- 1 980
- Bibliographic source:
- J.M. Contact dermatitis, 1980; 6: 138-139.
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin sensitisation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Seven patients with allergic contact dermatitis to ethylbutylthiourea (EBT) were tested for cross sensitivity to related alkyl-substituted thiourea compounds (including DBTU)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-dibutyl-2-thiourea
- EC Number:
- 203-674-6
- EC Name:
- 1,3-dibutyl-2-thiourea
- Cas Number:
- 109-46-6
- Molecular formula:
- C9H20N2S
- IUPAC Name:
- 1,3-dibutyl-2-thiourea
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- occupational
Results and discussion
- Clinical signs:
- Seven patients with allergic contact dermatitis to ethylbutylthiourea (EBT) were tested for cross sensitivity to related alkyl-substituted thiourea compounds.
=> 4 of the EBT-sensitive patients showed a positive reaction to dibutylthiourea.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
