Registration Dossier
Registration Dossier
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EC number: 270-219-6 | CAS number: 68413-47-8
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 March 2004 - 24 June 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Specific details on test material used for the study:
- - Description: light amber coloured, slightly viscous liquid
- Storage: room temperature, in the dark - Radiolabelling:
- no
- Details on study design: HPLC method:
- HPLC screening method
- Analytical monitoring:
- yes
- Details on sampling:
- Preparation of sample solution:
- Test material (0.1110) g) was diluted to 100 mL with acetonitrile.
Preparation of reference solution:
- The dead time was determined by measuring the retention time of formamide (purity* ≥99.5%, 641 mg/L solution in methanol). - Type:
- log Koc
- Remarks:
- Component 1. Dibutyl fumarate
- Value:
- 3.35 dimensionless
- Type:
- log Koc
- Remarks:
- Component 2. Registered substance
- Value:
- > 5.63 dimensionless
- Type:
- Koc
- Remarks:
- Component 1. Dibutyl fumarate
- Value:
- 2 240 dimensionless
- Type:
- Koc
- Remarks:
- Component 2. Registered substance
- Value:
- 427 000 dimensionless
- Statistics:
- The capacity factor was determined using the following equation:
K = (tr –t0) / t0
where:
k = capacity factor
tr = retention time (min)
t0 = dead time (min) - Validity criteria fulfilled:
- yes
- Conclusions:
- The log10 Koc for the test substance is >5.63 (SafePharm, 2004).
Reference
Description of key information
The log10 Koc for the test substance is >5.63 (SafePharm, 2004).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
