Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-809-6 | CAS number: 100-00-5
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Title:
- No information
- Author:
- Li Q, Minami M, Inagaki H (1998) Acute snd subchronic|immunotoxicity of p-chloronitrobenzene in mice.I. Effect on|natural killer, cytotoxic T-lymphocyte activities and|mitogen-stimulated lymphocyte proliferation. Toxicology 127:|223-232
Materials and methods
- Principles of method if other than guideline:
- other: see remark
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: T23-48:BDF1
- Sex:
- male
Administration / exposure
- Route of administration:
- other: i.p.
- Vehicle:
- other: olive oil
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 300 mg/kg bw/day
Basis:
- No. of animals per sex per dose:
- 20
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Type: other
Observation period: up to 14 days
Results and discussion
Any other information on results incl. tables
Result: NK cell activity inhibited (3rd d>14th d), CTL activity weaker on d3 (returned to contr. level on d7), LPS-stimulated lymphocyte proliferation weaker on d3, d7 (recovery up to d 14), no. of splenocytes increased, no diff. in Hb conc. and bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
