Esterification products of salicylic acid and C13-(branched) alcohols

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

5/1/2018 to 21/5/2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

11 July 2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

tridecyl 2-hydroxybenzoate

EC Number:

947-975-7

Molecular formula:

C20H32O3

IUPAC Name:

tridecyl 2-hydroxybenzoate

Specific details on test material used for the study:

Identification: Dermol TDSA
Appearance: Colourless to pale yellow clear liquid
Batch: P7202
Purity/Composition: UVCB
Test item storage: At room temperature
Stable under storage conditions until: 11 November 2021 (expiry date)
Additional information
Test Facility test item number: 209078/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Molecular structure: Not indicated
Molecular formula: C20H32O3
Molecular weight: 320
Test Item Characterization
The Sponsor provided to the Test Facility documentation of the identity, purity, composition, and stability for the test item(s). A Certificate of Analysis or equivalent document was provided to the Test Facility and is presented in Appendix 2.

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Test no.:

#1

Temp.:

ca. 20 °C

Vapour pressure:

ca. 0.01 Pa

Vapour pressure 2

Key result

Test no.:

#2

Temp.:

ca. 25 °C

Vapour pressure:

0.017 Pa

Any other information on results incl. tables

A representative weight loss curve of the test item is shown in Figure 3. The results of the isothermal TGA analysis for the test item and the vapour pressure at 20°Cand 25°Care given inTable 3andTable 4.

The vapour pressure regression curve of the log P_Tof the test item as function of the reciprocal temperatures is shown inFigure 4. The equation of the curve was: log P_T= -4182´1/T + 12.3 (r = 0.998, n = 8).

Table 3          
Results of the Vapour pressure Isothermal TGA Analysis

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	logPT	PT [Pa]
70	0.890448	1.06´10^-4	-3.97	0.05	1.1
	0.919489	1.10´10^-4	-3.96	0.07	1.2
80	1.76649	2.11´10^-4	-3.68	0.43	2.7
	1.82946	2.18´10^-4	-3.66	0.45	2.8
90	3.14177	3.75´10^-4	-3.43	0.75	5.6
	3.31015	3.95´10^-4	-3.40	0.78	6.0
100	5.14317	6.14´10^-4	-3.21	1.03	11
	5.38644	6.43´10^-4	-3.19	1.05	11

 

Table 4          
Vapour Pressure of the Test Item

Temperature [°C]	logPT	PT [Pa]	PT [mm Hg]
20	-2.00	1.0´10^-2	7.5´10^-5
25	-1.76	1.7´10^-2	1.3´10^-4

Applicant's summary and conclusion

Conclusions:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Dermol TDSA.
The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was:
20°C 25°C
[Pa] [mm Hg] [Pa] [mm Hg]
Test item 0.01 7.5 x 10-5 0.017 1.3 x 10-4

Executive summary:

In this guideline (OECD 104) study, [conducted with GLP certification], the isothermal TGA effusion method was applied for the determination of the vapour pressure of Dermol TDSA.

The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was:

      20°C       25°C

      [Pa]       [mm Hg]       [Pa]       [mm Hg]

Test item       0.01              7.5 x 10-5       0.017       1.3 x 10-4