(2-cyano-1-methylethyl)dodecylethylsulphonium tetrafluoroborate(1-)

Stability in organic solvents and identity of relevant degradation products

Link to relevant study record(s)

Reference

Endpoint:

stability in organic solvents and identity of relevant degradation products

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-10-21

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

The octanol stability of test substance was determined by measuring the concentration of test substance in n-octanol after a period of time and at equilibrium conditions and at ambient temperature.

GLP compliance:

no

Test substance stable:

yes

Remarks:

MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration slightly decreased within 7 days, but it was considered relatively stable in n-octanol.

Transformation products:

not measured

MTDID 15670 cation and anion stability in octanol were indicated by the peak ratio of the cation/internal standard or anion/internal standard over the period of seven days (Fig 1). Final concentrations of diluted MTDID 15670 sulfonium cation and PhI-Urea (IS) were 77.5 ng/mL and 98.0 ng/mL, respectively. The RSD% of MTDID 15670 cation concentration (4 time points) was 3.6% (data not shown). Final concentrations of diluted MTDID 15670 tetrafluoroborate anion and PFBS (IS) were 22.5 ng/mL and 98.0 ng/mL, respectively. The RSD% of MTDID 15670 anion concentration (4 time points) was 16% (data not shown).

 

MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration decreased slightly within 7 days, but it was consiered relatively stable in n-octanol.

Conclusions:

MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration slightly decreased within 7 days, but it was considered relatively stable in n-octanol.

Executive summary:

Stability of MTDID 15670 in n-octanol was studied over a period of seven days. MTDID 15670 contains a sulfonium cation component and a tetrafluoroborate anion component. The cation and anion components were analyzed separately, each at approximately day 0 (0 hour), day 3 (72 hours), day 4 (96 hour) and day 7(168 hour). MTDID 15670 cation and anion stability in octanol were indicated by the peak ratio of the cation/internal standard or anion/internal standard, respectively, over the period of seven days. MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration decreased slightly within 7 days, but it was considered relatively stable in n-octanol.

This is a non-GLP preliminary study followed general accepted scientific principles. It is considered reliable with restriction.

Description of key information

MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration slightly decr

eased within 7 days, but it was considered relatively stable in n-octanol.

Additional information

Stability of MTDID 15670 in n-octanol was studied over a period of seven days, by analyzing the cation and anion components separately, each at approximately day 0 (0 hour), day 3 (72 hours), day 4 (96 hour) and day 7 (168 hour). MTDID 15670 cation and anion stabilities in n-octanol were indicated by the peak ratio of the cation/internal standard or anion/internal standard, respectively, over the period of seven days. MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration decreased slightly within 7 days, but it was considered relatively stable in n-octanol.

This is a non-GLP preliminary study followed general accepted scientific principles. It is considered reliable with restriction.