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Description of key information

In vitro/in chemico skin sensitization studies were conducted on MTDID 28640. The results of the studies were:

 

-The test article was determined to have low reactivity (7.9% mean depletion) in a Direct Peptide Reactivity Assay (DPRA) (OECD 442C).

 

-The test article was positive (EC1.5: 47.74 uM) in the ARE-Nrf2 Luciferase test method (OECD 442D).

 

-The test article was negative (CD86: 89, CD54: 141) in the Human Cell Line Activation Test (h-CLAT) (OECD 442E).

Key value for chemical safety assessment

Justification for classification or non-classification

Based on the results of the studies, the test article is classified as a Category 1B sensitizer.