Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

There are no reliable irritation data for [2-(perfluorohexyl)ethyl]trichlorosilane (CAS 78560-45-9, EC 278-947-6). Severe skin, eye and respiratory damage would be expected due to release of HCl. However, in accordance with Column 2 of REACH Annex VIII, the in vitro skin irritation study (required in Section 8.1.1) and the in vitro eye irritation study (required in Section 8.2.1) do not need to be conducted as [2-(perfluorohexyl)ethyl]trichlorosilane hydrolyses rapidly in contact with water and moist air, releasing three moles of hydrogen chloride (HCl) for each mole of parent material. The production of hydrogen chloride indicates that the substance meets the criteria for classification as corrosive to skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no study available

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

[2-(Perfluorobutyl)ethyl]dichloro(methyl)silane is classified 'Skin Corr. 1A' and 'Eye Dam. 1', with hazard statements H314 'Causes severe skin burns and eye damage' and H318 'Causes serious eye damage' according to Regulation (EC) No 1272/2008.


[2-(Perfluorobutyl)ethyl]dichloro(methyl)silane is classified for respiratory corrosion, with hazard statement EUH071: 'Corrosive to the respiratory tract' according to Regulation (EC) No 1272/2008.