Registration Dossier
Registration Dossier
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EC number: 278-947-6 | CAS number: 78560-45-9
Endpoint summary
Administrative data
Description of key information
There are no reliable irritation data for [2-(perfluorohexyl)ethyl]trichlorosilane (CAS 78560-45-9, EC 278-947-6). Severe skin, eye and respiratory damage would be expected due to release of HCl. However, in accordance with Column 2 of REACH Annex VIII, the in vitro skin irritation study (required in Section 8.1.1) and the in vitro eye irritation study (required in Section 8.2.1) do not need to be conducted as [2-(perfluorohexyl)ethyl]trichlorosilane hydrolyses rapidly in contact with water and moist air, releasing three moles of hydrogen chloride (HCl) for each mole of parent material. The production of hydrogen chloride indicates that the substance meets the criteria for classification as corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
[2-(Perfluorobutyl)ethyl]dichloro(methyl)silane is classified 'Skin Corr. 1A' and 'Eye Dam. 1', with hazard statements H314 'Causes severe skin burns and eye damage' and H318 'Causes serious eye damage' according to Regulation (EC) No 1272/2008.
[2-(Perfluorobutyl)ethyl]dichloro(methyl)silane is classified for respiratory corrosion, with hazard statement EUH071: 'Corrosive to the respiratory tract' according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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