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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

There are no acute toxicity data for [2-(perfluorohexyl)ethyl]trichlorosilane (CAS 78560-45-9, EC 278-947-6). Acute toxicity tests by all routes are waived on the basis that the registered substance is classified as corrosive to skin 'Skin Corr. 1A', with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008.

The acute oral toxicity study on dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3), which was conducted according to OECD Test Guideline 423 (Acute Toxic Class Method, with minor deviations to Guideline dose levels) and in compliance with GLP, is included to support the data waiver for repeated dose toxicity (Hüls AG, 1997, Reliability 1).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The following read-across acute toxicity study data for dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3) is presented to support the data waiver for repeated dose toxicity.

In an acute oral toxicity study (Acute Toxic Class Method), single doses of undiluted dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3) were administered to Wistar rats by oral gavage (Hüls AG, 1997, Reliability 1). At 2000 mg/kg bw, 3/3 males died within 4h. At 200 mg/kg bw: 1/3 male died on day 6 and the remaining 2 males and 3 females were killed for humane reasons between days 6 and 8. On necropsy, inflammatory lesions of the digestive system were noticed (perforation of the oesophagus or the stomach in association with severe fibrinous inflammation of the adjacent tissues). At 25 mg/kg bw: 0/3 males and 0/3 females died showed only mild lesions, predominantly of the stomach (multifocal thickening of the gastric wall) in males, no macroscopic abnormalities in two females and severe lesions in the abdominal cavity in one female.

Justification for classification or non-classification

Classification for acute toxicity is not required as the substance is classified as corrosive to the skin 'Skin Corr. 1A', with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008.

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