Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 278-947-6 | CAS number: 78560-45-9
Endpoint summary
Administrative data
Description of key information
There are no acute toxicity data for [2-(perfluorohexyl)ethyl]trichlorosilane (CAS 78560-45-9, EC 278-947-6). Acute toxicity tests by all routes are waived on the basis that the registered substance is classified as corrosive to skin 'Skin Corr. 1A', with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008.
The acute oral toxicity study on dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3), which was conducted according to OECD Test Guideline 423 (Acute Toxic Class Method, with minor deviations to Guideline dose levels) and in compliance with GLP, is included to support the data waiver for repeated dose toxicity (Hüls AG, 1997, Reliability 1).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The following read-across acute toxicity study data for dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3) is presented to support the data waiver for repeated dose toxicity.
In an acute oral toxicity study (Acute Toxic Class Method), single doses of undiluted dichloro(3-chloropropyl)methylsilane (CAS 7787-93-1, EC 232-136-3) were administered to Wistar rats by oral gavage (Hüls AG, 1997, Reliability 1). At 2000 mg/kg bw, 3/3 males died within 4h. At 200 mg/kg bw: 1/3 male died on day 6 and the remaining 2 males and 3 females were killed for humane reasons between days 6 and 8. On necropsy, inflammatory lesions of the digestive system were noticed (perforation of the oesophagus or the stomach in association with severe fibrinous inflammation of the adjacent tissues). At 25 mg/kg bw: 0/3 males and 0/3 females died showed only mild lesions, predominantly of the stomach (multifocal thickening of the gastric wall) in males, no macroscopic abnormalities in two females and severe lesions in the abdominal cavity in one female.
Justification for classification or non-classification
Classification for acute toxicity is not required as the substance is classified as corrosive to the skin 'Skin Corr. 1A', with hazard statement H314 'Causes severe skin burns and eye damage' according to Regulation (EC) No 1272/2008.
.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
