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EC number: 278-947-6 | CAS number: 78560-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-05-27 to 1997-05-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 (Control), 6.7, 13.4, 33.4 and 66.8 mg/L and test stock solution.
- Sampling method: A series of concentrations of the test substance in distilled, deionised water were prepared to assess their stability. Their carbon content was measured initially and then again after 24, 48 and 72 hours. The concentration of the freshly prepared stock solution (in tap water) used to prepare the test media was also determined. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A 1000 mg/L stock solution was prepared by adding the test substance to tap water and then stirring for 18 hours followed by filtration.
- Controls: Tap water - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: Bio International B.V., Someren, Netherlands
- Length at study initiation (length definition, mean, range and SD): 2-3 cm
- Feeding during test: none
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: same as test
- Type and amount of food: TROUVIT at 1% of body weight per day
- Feeding frequency: daily
- Health during acclimation: <5% mortality in seven days prior to test - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 12 ºdH
- Test temperature:
- 20-21.9ºC
- pH:
- 8.0-8.5
- Dissolved oxygen:
- 89-98% ASV
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal initial loading rate of the test substance: 0 (Control) and 1000 mg/L.
Mean measured Dissolved Organic Carbon (DOC) concentration in fresh test media: 0 (Control) and 3.1 mg/L. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Aquaria
- Type: open
- Size, fill volume: 20 L with 10 L of test medium
- Aeration: yes
- Renewal rate of test solution: daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.69 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water from Gelsenwasser AG.
- Culture medium different from test medium: yes
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
EFFECT PARAMETERS MEASURED: mortality after 24, 48, 72 and 96 hours
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: limit test - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 3.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: hydrolysis products
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: based on measured DOC concentration
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 3.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: hydrolysis products
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: based on measured DOC concentration
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0
- Other adverse effects control: none - Reported statistics and error estimates:
- No effects were observed in the test and therefore statistical analysis was not required.
- Sublethal observations / clinical signs:
Table 1. Results of analysis of test media and stability test media
Nominal test substance loading (mg/L) Measured concentration at start (mg/L) Measured concentration after 24 h (mg/L) Measured concentration after 48 h (mg/L) Measured concentration after 72 h (mg/L) Mean measured concentration (mg/L) 66.8 66.8 54.8 56.3 53.7 57.9 33.4 31.2 28.0 27.4 26.8 28.4 13.4 13.3 11.3 13.1 12.2 12.5 6.7 6.8 5.1 5.2 7.0 6.0 Test medium (Test medium stock solution. Initial nominal loading rate of 1000 mg/L) 2.1 3.8 5.5 1.0 3.1 No toxic effects were observed in the Control or the only test concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96-hour LC50 value of >3.1 mg/L and a NOECof ≥3.1 mg/L have been determined for the effects of the test substance on mortality of Cyprinus carpio based on mean measured initial Dissolved Organic Carbon (DOC) concentration. The test medium was prepared at an initial loading rate of 1000 mg/L of the substance and was subsequently filtered before introducing the test organisms. The test substance hydrolyses in water and it is likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see the ecotoxicological discussion and aquatic toxicity endpoint summary for justification of read-across.
- Reason / purpose for cross-reference:
- read-across source
- Test organisms (species):
- Cyprinus carpio
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 3.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: hydrolysis products
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: based on measured DOC concentration
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 3.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: hydrolysis products
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: based on measured DOC concentration
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96-hour LC50 value of >3.1 mg/L and a NOECof ≥3.1 mg/L have been determined for the effects of the test substance on mortality of Cyprinus carpio based on mean measured initial Dissolved Organic Carbon (DOC) concentration. The test medium was prepared at an initial loading rate of 1000 mg/L of the substance and was subsequently filtered before introducing the test organisms. The test substance hydrolyses in water and it is likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
Referenceopen allclose all
Description of key information
Short-term toxicity to fish: 96-hour LC50 >3.1 mg/l (measured) (highest concentration tested) (OECD Guideline 203 (Fish, Acute Toxicity Test)), read-across from an analogous/structurally related substance, [2-(perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7, EC 257-473-3). The LC50 is equivalent to >2.6 mg/l when expressed in terms of the silanol hydrolysis product.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 2.6 mg/L
Additional information
There are no reliable short-term fish toxicity data available for [2-(perfluorohexyl)ethyl]trichlorosilane (CAS 78560-45-9, EC 278-947-6), therefore good quality data for an appropriate structural analogue, [2-(perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7), have been read across. Both substances have the same silanol hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol. The other hydrolysis products are hydrochloric acid and ethanol, respectively.
A 96-hour LC50 value of >3.1 mg/l and a NOEC of ≥3.1 mg/l (measured) (highest concentration tested) have been determined for the effects of [2-(perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7) on mortality of Cyprinus carpio based on mean measured initial Dissolved Organic Carbon (DOC) concentration. The test medium was prepared at an initial loading rate of 1000 mg/l of the substance and was subsequently filtered before introducing the test organisms.
In view of the test media preparation method/exposure regime it is possible that the long preparation time and high pH of the test solutions could influence the exposure of the organisms to [2-(perfluorohexyl)ethyl]triethoxysilane and its silanol hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol. However, due to the extremely low solubility of the test substance potentially limiting hydrolysis rate, it is unclear how much of the parent substance or silanol hydrolysis product was present in the test solution, but best use has been made of the available data.
The results may be expressed in terms of concentration of the hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol, by applying a molecular weight correction: (MW of silanol = 426.21 / MW of parent = 510.37) * >3.1 = >2.6 mg/l.
Refer to the discussion in IUCLID Section 6 for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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