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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

There are no reliable aquatic toxicity data available for [2-(perfluorohexyl)ethyl]trichlorosilane (CAS 78560-45-9, EC 278-947-6), therefore good quality data for the structurally-related substance, [2-(perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7, EC 257-473-3), have been read across.


Reliable short-term toxicity tests results are available for freshwater fish (Cyprinus carpio), invertebrates (Daphnia magna) and algae (Scenedesmus subspicatus) for [2-(perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7). The relevant short-term values are:


Fish: LC50 (96-hour): >3.1 mg/l (greater than the limit of solubility) (based on mortality) (highest concentration tested) (LC50 >2.6 expressed in terms of concentration of the hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol).

Daphnia: EC50 (48-hour): >9 mg/l (greater than the limit of solubility) (based on mobility) (highest concentration tested) (EC50 >7.5 expressed in terms of concentration of the hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol).

Algae: EC50 (72-hour): >7.1 mg/l; NOEC: ≥7.1 mg/l (greater than the limit of solubility) (based on growth rate) (highest concentration tested) (EC50 >5.9 mg/l and NOEC ≥5.9 mg/l expressed in terms of concentration of the hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol).


Activated sludge respiration inhibition: 3-hour EC50 values of >1300 mg/l and >100 mg/l (nominal) were determined in reliable studies, based on read-across from [2‑(Perfluorohexyl)ethyl]triethoxysilane (CAS 51851-37-7) and dichloromethyl(3,3,3‑trifluoropropyl)silane (CAS 675-62-7), respectively.

Test solution preparation for the fish, invertebrate and algal tests for the surrogate substance [2-(perfluorohexyl)ethyl]triethoxysilane, involved making a stock solution and stirring this for 18 hours prior to adding the test organisms. The pH during the fish test was 8.0 to 8.5 and the pH during the invertebrate test was measured as 7.9 to 8.0. The pH at the start of the algae test was 7.6 to 8.0. By the end of the algae test the pH had risen to 9.4 to 9.6. The surrogate substance will hydrolyse in water under dilute conditions, although rates are slower than that of the registration substance (half-life rates of the surrogate substance have been measured at 20°C as 1.44 hours at pH 4, 12.5 hours at pH 7 and 5.18 hours at pH 9). Given that the rate of hydrolysis is slowest at around pH 7 and increases as the pH is raised or lowered, , it is possible that pH could influence the exposure of the organisms to [2-(perfluorohexyl)ethyl]triethoxysilane and its hydrolysis product, [2-(perfluorohexyl)ethyl]silanetriol. The amount of silanol present in the test solution is dependent on how much of the parent substance was dissolved. The water solubility of the parent is extremely low and the test results show values above the limit of solubility. Measurements of the test substance in solution were made by dissolved organic carbon analysis (DOC). With DOC it is not possible to differentiate dissolved forms of the test substance and it is therefore unclear how much of the parent substance, silanol hydrolysis product or oligomer were dissolved in the test solution. However, there were no effects seen during the tests and so it can be concluded that no effects were seen at the limit of solubility of the test substance.

The presence of fluorocarbon chains means that the parent substance, silanol and condensation products have the potential for some surface activity. This is proven for the silanol based on measured and read-across data. The effective limits of solubility of both the parent substance and monomeric silanol hydrolysis products are very low because of the tendency to condense to oligomers which are of very low solubility. All forms of the substance may have a tendency to enrich at surfaces rather than forming stable evenly dispersed solutions. These phenomena may limit the extent of hydrolysis under conditions at which the solubility of either parent or oligomer is exceeded. The surrogate substance is extremely difficult to test and so best use has been made of the existing studies.

Therefore read-across is considered to be valid.