Registration Dossier
Registration Dossier
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EC number: 205-287-8 | CAS number: 137-29-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986 4 hour
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- traditional method
- Limit test:
- no
Test material
- Test material form:
- solid: crystalline
- Details on test material:
- Batch number 37160906202
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Cages made of polypropylene (38cmx56cmx18cm height) with detachable wire mesh tops and floors. The cags were suspended on a movable rack. While in their cages they had free access to a measured excess amount of food and tap water; food and water supplier are analysed routinely to determine the levels of chemical or microbiological contaminants.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- ca. 5.5 µm
- Details on inhalation exposure:
- Dust produced by a Wright dust generator
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Weight and wet type gas meter
- Duration of exposure:
- 4 h
- Concentrations:
- 0.0092, 0.017, 0.0020, 0.020, 0.090 and 0.482 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- 0.21 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating conc.
- Effect level:
- > 0.07 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 100% at 0.21mg/L and above
- Body weight:
- Survivors lost weight for up to 5 days and then gained weight normally
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Executive summary:
LC50 calculated to be between 0.07 and 0.21mg/L.
LC50 = 0.12mg/L
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