Registration Dossier
Registration Dossier
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EC number: 205-287-8 | CAS number: 137-29-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 days
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Test material form:
- solid: crystalline
- Details on test material:
- Batch number 37160906202
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- None supplied
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The material was prepared as 10% and 40% w/v suspensions in corn oil and administered by oral intubation at a range of sage volumes of 1.0 to 40mL/kg bodyweight. Rats were treated with vehicle alone (40mL/kg) served as controls
- Doses:
- 0, 0.1, 1.0, 4.0, 4.0, 16.0 g/kg
- No. of animals per sex per dose:
- 2 male and 2 female per dose
- Control animals:
- yes
- Details on study design:
- Observation period 14 days. Weighed weekly.
- Statistics:
- No deaths.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 other: b/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- Lethargy, diarrhoea and increased lacrimation amonst rats at 4.0g/kg and above.
Ptosis, for up to one hour after dosing amonst rates at 4.0 and 16g/kg
fur loss in two males at 4.0g/kg and one at 16g/kg
diuresis in two females and pallor if the extremities at 4g/kg
Pilo-erection was observed in all control rats accompanied by diuresis in one female. - Gross pathology:
- Pallor of the liver was observed in one male at 4.0g/kg (40w/v) and one female at 16g/kg at terminal autopsy. Other macroscopic findings were normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
