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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
(R)-quinuclidin-3-ol
EC Number:
246-857-6
EC Name:
(R)-quinuclidin-3-ol
Cas Number:
25333-42-0
Molecular formula:
C7H13NO
IUPAC Name:
quinuclidin-3-ol
Test material form:
solid: crystalline

Study design

Analytical method:
liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
-2.8
Temp.:
20 °C
pH:
7

Any other information on results incl. tables

Table 2: Powof the Test Item

Ratio
n-octanol : water [v:v]

Analyzed concentration

Pow

log Pow

pH

n-octanol
[g/L]

water
[g/L]

individual

mean

1:1

0.0000533

0.0357

1.5´10-3

1.6´10-3

-2.8

7.0

 

0.0000521

0.0344

1.5´10-3

 

-2.8

7.0

1:2

   0.0000421

0.0271

1.5´10-3

 

-2.8

7.0

 

   0.0000421

0.0266

1.6´10-3

 

-2.8

7.0

2:1

0.0000800

0.0490

1.6´10-3

 

-2.8

7.1

 

0.0000820

0.0522

1.6´10-3

 

-2.8

7.1

Mean

1.6´10-3

 

-2.8

 

Standard deviation

5.0´10-5

 

 

 

1        Estimated concentration in octanol phase, calculated by the extrapolation of the calibration curve.

Applicant's summary and conclusion

Conclusions:
The Pow value of the test item was 1.6 x 10-3. It corresponds with a log Pow value of -2.8.