Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Remarks:
Theoretical assessment taking all currently available relevant information into account.
Type of information:
other: expert statement
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Theoretical assessment taking all currrently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Guidance for the implementation of REACH. Guidance on information requirements and chemical safety assessment. Chapter R.7c: Endpoint specific guidance. European Chemical Agency
Version / remarks:
June 2017
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributylethylammonium ethyl sulphate
EC Number:
268-329-4
EC Name:
Tributylethylammonium ethyl sulphate
Cas Number:
68052-51-7
Molecular formula:
C14H32N . C2H5O4S (or C16H37NO4S)
IUPAC Name:
tributyl(ethyl)azanium ethyl sulfate

Results and discussion

Main ADME results
Type:
absorption
Results:
For risk assessment purposes, 50% is used for oral and dermal and 100% for inhalation absorption

Applicant's summary and conclusion

Conclusions:
A toxicokinetic assessment was performed based on the available data of the substance. Based on the physical/chemical properties of the substance, absorption factors for this substance are derived to be 50% (oral), 100% (inhalation) and 50% (dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low.