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Diss Factsheets

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Inhalation        Remove the victim from danger zone, avoid further exposure.

                         Consult a physician if irritating symptoms develop and persist.

Skin Contact    Remove contaminated clothing. Rinse contaminated skin immediately with plenty of water and seek medical advice.

Eye Contact     Immediately rinse eyes thoroughly with running water as long as possible (approx. 15 min).

                         Take injured quickly to factory medical center or call an ambulance (code word: eye accident).

Ingestion          Do not induce vomiting. In case of consciousness wash mouth with water and let drink some of water. Seek medical advice. Keep patient at rest.

Self-protection of the first aider

For personal protection see SDS Section 8

Fire-fighting measures

Extinguishing media

Suitable Extinguishing Media           Water spray or fog, foam, dry chemical powder, CO2, dry sand

Unsuitable Extinguishing Media      No restrictions

Special hazards arising from the substance or mixture

Dangerous Combustion Products     carbon oxides

                                                                nitrogen oxides

Advice for firefighters

Protective equipment for firefighters           Wear self-contained breathing apparatus and fire protective suite.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal precautions         Avoid contact with skin, eyes and clothing.

Environmental precautions

Environmental precautions     Must not be released into sewers, drains or wells.

Methods and material for containment and cleaning up

Methods for cleaning          Transfer large quantities into a container, rinse the rest with plenty of water.

Reference to other sections

For personal protection see Section 8, for disposal considerations see SDS Section 13

Handling and storage

Precautions for safe handling

Storage and Handling Precautions           Keep container tightly closed in a dry, cool and well-ventilated place. Ensure efficient exhaust ventilation when using t                                                                         his product

For Industrial Hygiene Measures see SDS Section 8, Exposure controls / Personal protection

Conditions for safe storage, including any incompatibilities

Conditions of storage                                  Protect against heat

Technical measures/ Precautions              Provide exhaust ventilation system in case of open handling.

Preventive Precautions (fire/explosion)    Take precautionary measures against static discharges.

Specific end use(s)

See SDS Subsection 1.2

Transport information

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

Control parameters

List type                                                                           mg/m3                                 /

Novartis internal Benchmark Guidance Value                 1                                       /

Exposure controls

Industrial Hygiene        The personal protective measure may be adapted appropriately when working in closed systems or under laboratory conditio                                           ns.

                                       Regular cleaning of equipment, work area and clothing.

                                       Controlled general ventilation or LEV (Local Exhaust Ventilation) mainly based on GMP requirements.

                                       Internal working procedures available to personnel covering personal hygiene, standard cleaning, waste disposal and mainten                                         ance.

                                       Personnel instructed and trained, regular refresher training established.

                                       Double wardrobe must be available.

Open Handling             Respiration : Disposable fine dust protection mask (EN149) or reusable halfmask (EN140)

                                       Filter : P3 (EN143)

                                       Eye : Safety glasses (EN166)

                                       Hand : Normal length chemical-mechanical resistant gloves (EN374/EN388)

                                       Glove Material : Nitrile

                                       Breakthrough time: 240 min

                                       Thickness: 0.4 mm

                                       Additional protection : working clothes (EN 340)

These values are derived from experiments, literature and information from the glove manufacturer.

They can also be derived from similar materials. In daily work please be aware that the using time depends on several factors and can be shorter than the oficially tested permeation time.

Stability and reactivity

Reaction products with water       no data available

Stability in solvents                        no data available

Hydrolysis                                       no data available

Materials to avoid                           strong oxidizing agents



Conditions to avoid                        moisture



For Incompatible materials see SDS Subsection 7.2 Conditions for safe storage, including any incompatibilities

Disposal considerations

Disposal Requirements           Incineration in an approved, controlled furnace with combustion gas scrubbing and emission gas control.

Container Disposal                  Clean container with water.

                                                   Store containers and offer for recycling of material according to the Environmental Protection (Duty of Care).