Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 231-397-0 | CAS number: 7531-52-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Guidance on Safe Use
Administrative data
First-aid measures
Inhalation Remove the victim from danger zone, avoid further exposure.
Consult a physician if irritating symptoms develop and persist.
Skin Contact Remove contaminated clothing. Rinse contaminated skin immediately with plenty of water and seek medical advice.
Eye Contact Immediately rinse eyes thoroughly with running water as long as possible (approx. 15 min).
Take injured quickly to factory medical center or call an ambulance (code word: eye accident).
Ingestion Do not induce vomiting. In case of consciousness wash mouth with water and let drink some of water. Seek medical advice. Keep patient at rest.
Self-protection of the first aider
For personal protection see SDS Section 8
Fire-fighting measures
Extinguishing media
Suitable Extinguishing Media Water spray or fog, foam, dry chemical powder, CO2, dry sand
Unsuitable Extinguishing Media No restrictions
Special hazards arising from the substance or mixture
Dangerous Combustion Products carbon oxides
nitrogen oxides
Advice for firefighters
Protective equipment for firefighters Wear self-contained breathing apparatus and fire protective suite.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal precautions Avoid contact with skin, eyes and clothing.
Environmental precautions
Environmental precautions Must not be released into sewers, drains or wells.
Methods and material for containment and cleaning up
Methods for cleaning Transfer large quantities into a container, rinse the rest with plenty of water.
Reference to other sections
For personal protection see Section 8, for disposal considerations see SDS Section 13
Handling and storage
Precautions for safe handling
Storage and Handling Precautions Keep container tightly closed in a dry, cool and well-ventilated place. Ensure efficient exhaust ventilation when using t his product
For Industrial Hygiene Measures see SDS Section 8, Exposure controls / Personal protection
Conditions for safe storage, including any incompatibilities
Conditions of storage Protect against heat
Technical measures/ Precautions Provide exhaust ventilation system in case of open handling.
Preventive Precautions (fire/explosion) Take precautionary measures against static discharges.
Specific end use(s)
See SDS Subsection 1.2
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Control parameters
List type mg/m3 /
Novartis internal Benchmark Guidance Value 1 /
Exposure controls
Industrial Hygiene The personal protective measure may be adapted appropriately when working in closed systems or under laboratory conditio ns.
Regular cleaning of equipment, work area and clothing.
Controlled general ventilation or LEV (Local Exhaust Ventilation) mainly based on GMP requirements.
Internal working procedures available to personnel covering personal hygiene, standard cleaning, waste disposal and mainten ance.
Personnel instructed and trained, regular refresher training established.
Double wardrobe must be available.
Open Handling Respiration : Disposable fine dust protection mask (EN149) or reusable halfmask (EN140)
Filter : P3 (EN143)
Eye : Safety glasses (EN166)
Hand : Normal length chemical-mechanical resistant gloves (EN374/EN388)
Glove Material : Nitrile
Breakthrough time: 240 min
Thickness: 0.4 mm
Additional protection : working clothes (EN 340)
These values are derived from experiments, literature and information from the glove manufacturer.
They can also be derived from similar materials. In daily work please be aware that the using time depends on several factors and can be shorter than the oficially tested permeation time.
Stability and reactivity
Reaction products with water no data available
Stability in solvents no data available
Hydrolysis no data available
Materials to avoid strong oxidizing agents
acids
bases
Conditions to avoid moisture
heat
light
For Incompatible materials see SDS Subsection 7.2 Conditions for safe storage, including any incompatibilities
Disposal considerations
Disposal Requirements Incineration in an approved, controlled furnace with combustion gas scrubbing and emission gas control.
Container Disposal Clean container with water.
Store containers and offer for recycling of material according to the Environmental Protection (Duty of Care).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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