4-Butoxy-2,3-difluorophenylboronic Acid (contains varying amounts of Anhydride)

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12.12.2017

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Decomposition:

yes

Decomp. temp.:

> 130 °C

Two DSC measurements with a heating rate of 10 K/min showed an endothermal effect (melting) in the temperature range of 90 - 150 °C. This endothermal effect was directly followed by an exothermal effect. The onset temperature was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The results of the DSC measurements are summarized in Table 1.

Table 1: Melting point (DSC measurements)

Ident No.	Test item/ mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endothermal) / °C	Onset (melting)/ °C	Crucible	Observations after the measurement
36743	13.73	25	500	90 - 150	127.37	Aluminium with a hole	Test item was discoloured to black, Mass loss: 82 %
36744	17.84	25	150	105 - 150	129.84	Aluminium with a hole	Test item was a solidified melt, Mass loss: 13 %

 

The test item had no boiling point under atmospheric conditions. Decomposition started after melting.

Conclusions:

No boiling point determinable. The substance melted under decomposition.

Executive summary:

A study was conducted according to OECD test guideline 103 and Regulation (EC) No 440/2008 method A.2 to determine the boiling point of the test item using differential scanning calorimetry (DSC 25 -150 °C). The test item and the reference are heated up from the starting temperature to the final temperature at a constant heating rate in a defined atmosphere (nitrogen). Open crucibles are used as containers for the test item and as empty reference crucible. The quantity of heat absorbed or released is measured and recorded.

Under consideration of the result from the melting point it was concluded that the test item had no boiling point under atmospheric conditions. Decomposition started during melting.

Description of key information

A study was conducted according to OECD test guideline 103 and Regulation (EC) No 440/2008 method A.2 to determine the boiling point of the test item using differential scanning calorimetry (DSC 25 -150 °C). The test item and the reference are heated up from the starting temperature to the final temperature at a constant heating rate in a defined atmosphere (nitrogen). Open crucibles are used as containers for the test item and as empty reference crucible. The quantity of heat absorbed or released is measured and recorded.

Under consideration of the result from the melting point it was concluded that the test item had no boiling point under atmospheric conditions. Decomposition started during melting.