Registration Dossier
Registration Dossier
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EC number: 243-020-7 | CAS number: 19395-41-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Derek Nexus 6.0
- Year:
- 2 017
- Bibliographic source:
- Derek for Windows - Skin Sensitisation
Materials and methods
- Principles of method if other than guideline:
- - Software tool(s) used including version:
Derek Nexus 6.0
- Model(s) used: for Windows - Skin Sensitisation
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- no
Test material
- Reference substance name:
- α-phenylpiperidine-2-acetic acid
- EC Number:
- 243-020-7
- EC Name:
- α-phenylpiperidine-2-acetic acid
- Cas Number:
- 19395-41-6
- Molecular formula:
- C13H17NO2
- IUPAC Name:
- α-phenylpiperidine-2-acetic acid
- Test material form:
- solid: granular
Constituent 1
- Specific details on test material used for the study:
- C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O
Results and discussion
In vitro / in chemico
Results
- Parameter:
- other: (Q)SAR
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance falls within the applicability domain described above and therefore, the predicted value can be considered reliable.
The query structure does not match any structural alerts or examples for skin sensitisation in Derek. Additionally, the query structure does not contain any unclassified or misclassified features and is consequently predicted to be a non-sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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