Registration Dossier
Registration Dossier
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EC number: 276-851-9 | CAS number: 72797-41-2
Density
Administrative data
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August to november 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The determination was carried out by a gas comparison pycnometer method, using a procedure designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
Test material
- Reference substance name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- EC Number:
- 276-851-9
- EC Name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- Cas Number:
- 72797-41-2
- Molecular formula:
- C21H25ClN2O4S
- IUPAC Name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- Test material form:
- solid: crystalline
- Details on test material:
- White powder
Constituent 1
- Specific details on test material used for the study:
- Batch 18114773 - Purity > 99.5%
Instrument: Multi-Pycnometer, Quantachrome, Syosset, N.Y., USA
Calibration sphere: A stainless steel sphere with a known volume (Vcal = 56.559 cm3)
Gas: Helium
Results and discussion
Densityopen allclose all
- Key result
- Type:
- relative density
- Density:
- ca. 1.33
- Temp.:
- 20 °C
- Type:
- density
- Density:
- ca. 1 330 kg/m³
- Temp.:
- 20 °C
Applicant's summary and conclusion
- Conclusions:
- Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.
The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Increasing the temperature of a substance may decrease its density by increasing thevolume of that substance. Typical thermal expansion coefficients of solids are in the order of 10-5 °C-1,and the volumetric expansion of stainless steel (used as calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Therefore, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance.
Therefore, it was considered that the difference in temperature between 20.0 °C and normal laboratory conditions did not have a significant
The density of the test item has been determined to be 1.23 x 10E3 kg/m3 at 19.0 ± 1.0 °C; relative density: 1.23. - Executive summary:
The density of the test item has been determined to be 1.23 x 10E3 kg/m3 at 19.0 ± 1.0 °C; relative density: 1.23.
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