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EC number: 236-818-1 | CAS number: 13497-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 - 20 Nov 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- following OSPAR PARCOM Protocol, marine fish, semi-static
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Control and nominal loading rate of 200 mg/L
- Sampling method: 4 mL samples of the test media were taken at the start and end of each successive 48 h exposure period (total exposure period of 96 h)
- Sample storage conditions before analysis: Samples analysed immediately after collection. Retained samples were stored at -20 °C - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test item was added to the test vessel containing dilution water and stirred for 1 hour prior to introducing the fish.
- Controls: Dilution water - Test organisms (species):
- other: Scophthalmus maximus
- Details on test organisms:
- TEST ORGANISM
- Common name: Turbot
- Source: Venö Fish Farm, Venö, Denmark
- Diameter at study initiation (mean and SD): 5 +/-1 cm
- Feeding during test: no
ACCLIMATION
- Acclimation period: 15 days
- Acclimation conditions: same as test
- Type and amount of food: DANA Feed 1362, 1.8 mm granulate
- Feeding frequency: Twice per day for at least 5 days per week
- Health during acclimation (any mortality observed): No fish died during the acclimation period - Test type:
- semi-static
- Water media type:
- saltwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- not reported
- Test temperature:
- 14.2-14.7°C
- pH:
- 7.8-8.6
- Dissolved oxygen:
- ≥60% ASV
- Salinity:
- 33.5 ppm
- Nominal and measured concentrations:
- Control and nominal loading rate of 200 mg/L
Mean measured concentrations of the test substance (based on DOC) were 113 and 118% of nominal in the two replicates. - Details on test conditions:
- TEST SYSTEM
- Test vessel: aquarium
- Type: open
- Material, size, fill volume: glass, 10 litre with 7 L fill volume
- Aeration: yes
- Renewal rate of test solution: after 48 hours
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Articial seawater prepared using "Reef Salt", Aqua Medic GmbH, Bissendorf, Germany by adding 33.5 g/L of salts to tap water and stirring for 24 hours.
- Ca/mg ratio: 1:2.9
- Culture medium different from test medium: no
- Intervals of water quality measurement: Daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 12 h light, 12 h dark
EFFECT PARAMETERS MEASURED: Mortality daily
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test
- Range finding study
- Test concentrations: 1, 10, 50, 100, 200, 500 and 1000 mg/L
- Results used to determine the conditions for the definitive study: No mortality at any concentration - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0%
- Reported statistics and error estimates:
- There were no toxic effects observed in the test and therefore statistical analysis of the results was not required.
- Sublethal observations / clinical signs:
Table 1. Results of analysis of test media
Nominal test substance concentration (mg/L)
Nominal test substance concentration as TOC (mg/L)
Measured DOC concentration in fresh test medium at start of test (mg/L)
Measured DOC concentration in old test medium after 48 hours (mg/L)
Measured DOC concentration in fresh test medium at 48 hours (mg/L)
Measured DOC concentration in old test medium after 96 hours (mg/L)
0 (Control)
0
8.2
20
18
3.7
200 (Rep. 1)
84
115
97
97
84
200 (Rep. 2)
84
100
97
97
84
Since no toxic effects were observed up to the highest tested concentration the NOEC (96 h) was >= 200 mg/L.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96-h LC50 value of >200 mg/L and a NOEC of ≥200 mg/L have been determined for the effects of the test substance on mortality of the marine fish species Scophthalmus maximus based on nominal exposure concentrations.
Reference
Description of key information
LC50 (96 h) > 200 mg/L (nominal, Scophthalmus maximus, OECD 203)
Key value for chemical safety assessment
Marine water fish
Marine water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 200 mg/L
Additional information
Experimental data are available testing the acute toxicity of 3-(triethoxysilyl)-N-[3-(triethoxysilyl)propyl]-1-propanamine (CAS No. 13497-18-2) towards fish. The study was performed according to the OECD guideline 203 and GLP standards (2004). The salt water organism Scophthalmus maximus was used for testing and was exposed for 96 h in a semi-static testing regime to one single test item concentration of 200 mg/L and a control. The test item was monitored during the test via measurement of DOC. The recoveries of the test substance were 113 and 118% of the nominal concentration and therefore results refer to nominal values. No toxic effects were recorded and thus the study resulted into a 96-h LC50 value of > 200 mg/L and a NOEC of ≥ 200 mg/L (nominal).
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