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EC number: 246-850-8 | CAS number: 25327-89-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- November 1981
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- eye rinsed after 30sec instead of 1 hour and not all the required data are given in the test report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The eyes of the tested animals were rinsed after 30 seconds instead of 1 hour.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1'-isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]
- EC Number:
- 246-850-8
- EC Name:
- 1,1'-isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]
- Cas Number:
- 25327-89-3
- Molecular formula:
- C21H20Br4O2
- IUPAC Name:
- 1,1'-isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Each rabbit was sexed, weighted and ear tagged with a unique animal numer (weight range: 1.95 kg to 2.55kg). The rabbts were quarantined and acclimated to laboratory conditions for 12 days prior to initiation of the study. The rabbits were individually housed in stain-less steel wire-bottomed cages suspended above the droppings. Animals were observed twice daily during the quarantine period.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100mg applied to the right eye - 6 not rinsed and 3 rinsed after 30 seconds
- Duration of treatment / exposure:
- Single dose
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 9 animals (4 males and 5 females)
- Details on study design:
- Grading for irrittation and injury were made at 24, 48 and 72 hours and at 4 and 7 days, using the standard scoring system of Draize. Fluoroscein examinations were used to facilitate evaluation of potential corneal damage.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48/72 h - 4d - 7d
- Score:
- >= 0 - <= 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h for rinsed animals - 7 days for not rinsed animals
- Irritant / corrosive response data:
- The primary irritation index was calculated to be 4.0 for the not rinsed test animals and 1.33 for the rinsed test animals.
- Other effects:
- no signs of systemic toxicity and no deaths occurred
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not classified as irritant for eyes.
- Executive summary:
The primary eye irritation index was calculated to be 1.33 for the rinsed test animals and all the effects were completely reversible after 72h, therefore the substance is not classified as irritant for eyes.
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