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EC number: 246-850-8 | CAS number: 25327-89-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1'-isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]
- EC Number:
- 246-850-8
- EC Name:
- 1,1'-isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]
- Cas Number:
- 25327-89-3
- Molecular formula:
- C21H20Br4O2
- IUPAC Name:
- 1,1'-isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rats were quarantined and acclimated to laboratry conditions for 14 days prior the initiation of the study. Animals were observed twice daily during the quarantine period. In the last day of the quarantine period, one group consisting of ten rats (5 males and 5 females) were selected and used for the study.
The animals were randomly placed in numbered cages. Each rat was sexed, weighted and ear punched. Body weights ranged from 212 to 268g. The rats were individually housed in wire-bottomed cages suspended above the droppings.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Details on oral exposure:
- One solution of test material and vehicle was made using corn oil (33.3% w/v). The amount of test material vehicle solution was measured in a plastic disposable syringe and administered directly in the rat's stomach as a single dose using a rubber catheter and tubing adapter.
Individual dose amounts were calculated using fasted body weights, taken prior to dosing. - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Water and food were offered ad libitum, except during the 4 hours period immediately prior to oral intubation, when food was withheld.
Approximately one hour after dosing, food was offered.
All animals selected for the study were weighted on days -1, 0, 6 and 13.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no deaths occurred
- Clinical signs:
- other: no abnoralities were observed
- Gross pathology:
- no abnoralities were observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 5000 mg/kg bw
- Executive summary:
The test substance was evalueted for its acute oral toxicity potential in rats. The study was performed according to GLP following oral administration of a single dose to the rat.
No mortality occurred during the study and no abnormalities were observed.
There was no effect on body weight gain.
The gross necropsy conducted at termination of the study revealed no observable abnormalities.
The acute oral LD50 was determined to be greater than 5000 mg/kg bw.
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