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EC number: 807-159-2 | CAS number: 69701-99-1
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Jan 2020 - 31 Jan 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Appearance/Physical state: clear, colourless, liquid
- Batch: 09892803
- Purity: 98.8% which excludes optical isomer
- Expiry / Retest date: 15 February 2023
- Storage conditions: room temperature, in the dark - Test temperature:
- 30 °C
- Details on study design: HPLC method:
- The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System: Agilent Technologies 1100, incorporating workstation and autosampler
Detector type: variable wavelength (VW)
Column: XSelect HSS Cyano 5µ (150 x 4.6 mm id)
Column temperature: 30 °C
Mobile phase: methanol: water (55:45 v/v)
pH of mobile phase: 6.7
Flow-rate: 1.0 mL/min
Injection volume: 10 µL
VW detector wavelength: 210 nm - Details on sampling:
- Performance of the Test
Preparation of dead time solution
The dead time was determined by measuring the retention time of a solution of formamide (purity* 99.6%) at 600 mg/L in methanol: water (55:45 v/v).
Preparation of reference standard solutions
Solutions of reference standards (please refer to table 1 in 'Any other materials and methods incl. tables) were prepared in methanol.
Preparation of sample solution
Test item (0.1030 g) was diluted to 100 mL with methanol and diluted by a factor of 2 with methanol to give a concentration of 515 mg/L. - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- 1.14
- Temp.:
- 30 °C
- Remarks on result:
- other: The adsorption coefficient of the test item has been determined to be 13.8, log10 Koc of 1.14.
- Details on results (HPLC method):
- Please refer to ' Any other information on results incl. tables).
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of MEDOL-10 has been determined to be 13.8, log10Koc 1.14.
- Executive summary:
Introduction
The adsorption coefficient of MEDOL-10 has been determined to be 13.8, log10Koc 1.14, using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001..
Results
Please refer to 'Any other information on results incl. tables'.
Conclusion
The adsorption coefficient of MEDOL-10 has been determined to be 13.8, log10Koc 1.14.
Reference
Adsorption Coefficient
The retention time, capacity factor and log10 Koc values determined for
the sample are shown in the following table:
| Injection | Retention Time (min) | Capacity Factor (k') | Log10 k' | Log10 Koc |
| 1 | 3.018 | 0.561 | -0.251 | 1.14 |
| 2 | 3.018 | 0.561 | -0.251 | 1.14 |
The retention times of the dead time and the retention times, capacity factors and log10 Koc values for the reference standards are shown in the following table:
| Standard | Retention Time (min) | Mean Retention Time (min) | Capacity Factor (k') | Log10 k' | Log10 Koc | |
| Injection 1 | Injection 2 | |||||
| Formamide (dead time) | 1.934 | 1.934 | 1.934 | - | - | - |
| Acetanilide | 2.678 | 2.676 | 2.677 | 0.385 | -0.415 | 1.25 |
| Atrazine | 3.721 | 3.731 | 3.726 | 0.927 | -3.28 x 10-2 | 1.81 |
| Isoproturon | 3.981 | 4.005 | 3.993 | 1.065 | 0.0274 | 1.86 |
| Triadimenol | 5.442 | 5.432 | 5.437 | 1.812 | 0.258 | 2.4 |
| Linuron | 5.602 | 5.57 | 5.586 | 1.889 | 0.276 | 2.59 |
| Naphthalene | 4.779 | 4.777 | 4.778 | 1.471 | 0.168 | 2.75 |
| Endosulfan-diol | 6.967 | 6.96 | 6.964 | 2.602 | 0.415 | 3.02 |
| Fenthion | 8.455 | 8.396 | 8.426 | 3.358 | 0.526 | 3.31 |
| α-Endosulfan | 11.953 | 11.931 | 11.942 | 5.176 | 0.714 | 4.09 |
| Diclofop-methyl | 12.96 | 12.996 | 12.978 | 5.712 | 0.757 | 4.2 |
| Phenanthrene | 9.085 | 9.088 | 9.087 | 3.699 | 0.568 | 4.09 |
| DDT | 25.873 | 25.738 | 25.805 | 12.346 | 1.09 | 5.63 |
Description of key information
A soil adsorption coefficient measurement was conducted on MEDOL-10 (Covance Laboratories Limited, 2020, Study XN35KK). The study was performed according to OECD test guideline 121 and EU Method C.19, and in compliance with GLP.
The soil adsorption coefficient was determined by the HPLC method. The soil adsorption coefficient of MEDOL-10 was determined to have a Koc = 13.8, equivalent to a log10Koc value of 1.14, signifying that MEDOL-10 is highly mobile in soil and is not likely to be strongly adsorbed onto soil and organic matter.
Key value for chemical safety assessment
- Koc at 20 °C:
- 13.8
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