Registration Dossier
Registration Dossier
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EC number: 268-799-0 | CAS number: 68140-48-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-[2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-inden-5-yl]ethan-1-one
- EC Number:
- 268-799-0
- EC Name:
- 1-[2,3-dihydro-1,1,2,6-tetramethyl-3-(1-methylethyl)-1H-inden-5-yl]ethan-1-one
- Cas Number:
- 68140-48-7
- Molecular formula:
- C18H26O
- IUPAC Name:
- 1-[1,1,2,6-tetramethyl-3-(propan-2-yl)-2,3-dihydro-1H-inden-5-yl]ethan-1-one
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2.01; 2.41; 2.89; 3.47 or 4.17mL / kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2.22 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 2.03 - 2.44
- Mortality:
- Death ocurred between 3h and 7 days after dosing.
- Clinical signs:
- Rats shiwed sluggishness and humpback behaviour. Some of the rats lost consiousness. Within 24 hours after treatment green.coloured urine was observed in all dose groups.
After 24 hours all rats showed urine stains on the fur of the abdominal region. They produced red coloured urine. - Body weight:
- Males: 122 - 236 g
Females: 95-195 g
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The material can be classified as slightly toxic.
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