Registration Dossier
Registration Dossier
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EC number: 237-997-9 | CAS number: 14154-09-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
During the literature search and data gap analysis it became obvious that the overall database on substance-specific human health hazard data for trimanganese bis(orthophosphate) is too scant to cover all REACH endpoints. Therefore, the remaining data gaps had to be covered by either experimental testing or read-across from similar substances.
Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the phosphate moiety and the manganese moiety (or one of its readily soluble salts). This way forward is acceptable, since trimanganese bis(orthophosphate) dissociates to the phosphate anion and the manganese cation upon dissolution in aqueous media.
Once the individual constituents of trimanganese bis(orthophosphate) become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the “overall” toxicity of the dissociated substance can be described by the toxicity of the “individual” constituents. Since synergistic effects are not expected, the human health hazard assessment consists of an individual assessment of the manganeses cation and the phosphate anion.
The hazard information of the individual constituents was obtained from publicly available literature (i.e. EFSA documents, ATSDR toxicological profile and WHO recommendations for human nutrition).
Trimanganese bis(orthophosphate) readily dissociates to the corresponding manganese cations and phosphate anions. The manganese cation and the phosphate anion are considered to represent the overall toxicity of trimanganese bis(orthophosphate) in a manner proportionate to the phosphate and the metal (represented by one of its readily soluble salts). Based on the above information, unrestricted read-across is considered feasible and justified.
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