(tert-butoxymethyl)oxirane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-03-16 to 2018-04-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

Name: tert-Butyl glycidyl ether
CAS No.: 7665-72-7
Batch No.: ZMG-195668
Appearance: Clear colourless liquid
Molecular formula: C7H14O2
Content: 99.8% (area)
Storage conditions: Cool, protected from light
Expiry date: 07 March 2019

Key result

Water solubility:

90.3 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

6.4

Check of the temperature

The measured temperatures at the pre-incubation and the thermostatisation phase are summarized in Table 1. The additional manual values confirm the values of the data logger.

Table 1: Temperature at pre-incubation (30 °C) and thermostatisation phase (20 °C) (measured hourly)

Intended temperature [°C]	Measured temperature [°C]
	min.	max.	Mean value ± SD
30.0 ± 0.5	29.93	30.11	30.02 ± 0.04
20.0 ± 0.5	20.02	20.38	20.09 ± 0.07

Check of pH-value

The pH-values were determined with the remaining test item mixtures in the original test vessels which were kept constant at 20 ± 0.5 °C. pH-values of the test mixtures are summarized in Table 2.

Table 2: pH-value of the test mixture for double distilled water

Test temperature [°C]	Pre‑incubation time [h]	Replicate	Measured pH	Mean value
20	24	1	6.331	6.4
		2	6.444
	48	1	6.399
		2	6.409
	72	1	6.598
		2	6.472
		Control	6.151	‑

Check of Tyndall-effect

No Tyndall-effect was observed for any of the centrifuged samples.

Water solubility results

No significant signals were obtained for the control sample. The water solubility results of the test item are summarized in Table 3.

Table 3: Water solubility results at 20 °C for tert-Butyl glycidyl ether

Pre-incubation time	Replicate	tert‑Butyl glycidyl ether [g/L]
		Concentration*	Mean
24 h	1	90.5	90.6
	2	90.7
48 h	1	90.2	90.1
	2	90.1
72 h	1	90.1	90.1
	2	90.1
Mean (24 - 72 h)			90.3
Deviation [%] (24 - 72 h)			0.6

* mean value of two injections, dilution factor of 10 and exact weight of the standard taken into account

Validity criteria

The validity criteria were fulfilled:

- The concentration measured at each sampling time did not differ for more than 15%

- Temperatures were kept constanct within ± 0.5 °C.

Conclusions:

The water solubility of the test item at 20 °C was 90.3 g/L (pH 6.4).

Executive summary:

The water solubility of the test item was determined according to OECD test guideline 105 using the flask method. The mean water solubility for three pre-incubation times 24 h, 48 h and 72 h was 90.3 g/L and a mean pH of 6.4 was observed. The validity criteria were fulfilled.

Description of key information

The water solubility of the test item was determined according to OECD test guideline 105 using the flask method. The mean water solubility for three pre-incubation times 24 h, 48 h and 72 h was 90.3 g/L and a mean pH of 6.4 was observed. The validity criteria were fulfilled.

Key value for chemical safety assessment

Water solubility:

90.3 g/L

at the temperature of:

20 °C