Registration Dossier
Registration Dossier
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EC number: 200-460-4 | CAS number: 60-18-4
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- CRC Handbook of chemistry and physics.
- Author:
- Lide, D.R.
- Year:
- 1 993
- Bibliographic source:
- 73th edition, 1992-1993, ISBN 0-8493-0473-3
Materials and methods
- Principles of method if other than guideline:
- No information is available on the testing protocol.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tyrosine
- EC Number:
- 200-460-4
- EC Name:
- Tyrosine
- Cas Number:
- 60-18-4
- Molecular formula:
- C9H11NO3
- IUPAC Name:
- tyrosine
Constituent 1
Results and discussion
Dissociation constantopen allclose all
- No.:
- #1
- pKa:
- 2.2
- Temp.:
- 21 °C
- Remarks on result:
- other: pKa: Negative of the logarithm of the dissociation constant for the alpha-COOH group
- No.:
- #2
- pKa:
- 9.11
- Temp.:
- 21 °C
- Remarks on result:
- other: pKb: Negative of the logarithm of the dissociation constant for the alpha-NH3+ group
- No.:
- #3
- pKa:
- 10.07
- Temp.:
- 21 °C
- Remarks on result:
- other: pKx: Negative of the logarithm of the dissociation constant for any group present in the molecule.
Applicant's summary and conclusion
- Conclusions:
- The pKa is 2.2 and the pKb is 9.11.
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