Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-687-5 | CAS number: 367-25-9
Sediment toxicity
Administrative data
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 218 (Sediment-Water Chironomid Toxicity Test Using Spiked Sediment)
- Version / remarks:
- 13 Apr 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,4-difluoroaniline
- EC Number:
- 206-687-5
- EC Name:
- 2,4-difluoroaniline
- Cas Number:
- 367-25-9
- Molecular formula:
- C6H5F2N
- IUPAC Name:
- 2,4-difluoroaniline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Chironomus riparius
Study design
- Study type:
- laboratory study
- Test type:
- static
- Water media type:
- freshwater
- Type of sediment:
- artificial sediment
- Limit test:
- no
Exposure duration
- Duration:
- 28 d
- Exposure phase:
- total exposure duration
Test conditions
- Nominal and measured concentrations:
- Control, 7.81, 15.63, 31.25, 62.5, and 125 mg/kg (nominal)
Control, 6.38, 12.70, 26.30, 51.0, and 108 mg/kg (initial measured) - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 99.2 mg/kg sediment dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- emergence rate
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 108 mg/kg sediment dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- development rate
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 51 mg/kg sediment dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- emergence rate
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 108 mg/kg sediment dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- development rate
- Details on results:
- The sex ratio (percentage males) of emerged midges was significantly affected at 108 mg/kg.
Applicant's summary and conclusion
- Conclusions:
- The EC50 (28 d) for the emergence and development rate were 99.2 and > 108 mg/kg, respectively.
The NOEC (28 d) for emergence and development rate were 51 and 108 mg/kg, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
