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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: poisoning incident
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study, meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Severe methanol intoxication.
Author:
Erlanson, P. et al.
Year:
1965
Bibliographic source:
Acta Med Scand 177: 393-408

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Principles of method if other than guideline:
Data from poisoning incident in humans.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Methanol
EC Number:
200-659-6
EC Name:
Methanol
Cas Number:
67-56-1
Molecular formula:
CH4O
IUPAC Name:
methanol
Details on test material:
- Name of test material (as cited in study report): methanol (not further specified)
- Physical state: liquid
- Analytical purity: no data

Method

Subjects:
- Number of subjects exposed: 4
- Sex: male
Route of exposure:
oral
Reason of exposure:
accidental
Exposure assessment:
measured

Results and discussion

Results of examinations:
Four cases of methanol poisoning were treated with alkali, ethyl alcohol, and the haemodialysis. In 3 cases respirator treatment was also required. Severe acidosis, failing eye-sight, and cerebral damage were present at the start of treatment within 29 to 44 hours of the methanol ingestion. Three patients, one of whom had consumed 90 g, died despite correction of the acidosis and elimination of methanol.
Autopsy in these cases showed massive necrosis of the brain and haemorrhages into the putamina. The fourth patient, who had consumed 80 g methanol, survived but died 1 1/2 year later from pneumonia; autopsy showed slit-shaped cysts in the lateral parts of the putamina. All the patients had considerable hypopotassaemia.

Applicant's summary and conclusion