Registration Dossier
Registration Dossier
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EC number: 207-856-6 | CAS number: 498-15-7
Endpoint summary
Administrative data
Description of key information
delta-3 -Carene was found to be a skin-sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
delta-3 -Carene was tested for skin sensitisation in female Dunkin-Hartley guinea pigs. Groups of guinea pigs (10 or 12/group) received four occluded dermal exposure for 24 hours in scapular region of 50% delta-3-carene followed by challenge dose on the shaven flanks with 10, 3, 1% and vehicle.
In the first set of experiments 8 out of 12 and in second, 7 out of 10 animals showed presence of erythema which was considered as positive reaction.
Therefore, delta-3-carene was found to be a skin-sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
As delta-3-carene showed clear signs of skin sensitisation, it is classified as skin sensitiser category 1B, H317 according to CLP Regulation (EC) N° 1272/2008 and as skin sensitiser "Xi, R43: May cause sensitisation by skin contact" according to Directive 67/548/EEC.
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